Hydrobromides
Apexbio Technology LLC A 61603 hydrobromide 107756-30-9 10mg
A 61603 hydrobromide (CAS 107756-30-9) is a potent and highly selective agonist of the 1A-adrenergic receptor one of the 1-adrenergic receptor subtypes involved in cellular growth and proliferation Compared to its activity at 1B- and 1D-adrenergic receptors A 61603 demonstrates approximately 35-fold higher potency for 1A-AR In cellular assays it robustly induces phosphoinositide hydrolysis in 1A-AR-expressing fibroblasts (pEC50 8 24) and in neonatal rat cardiomyocytes it increases calcium transient frequency in a dose-dependent manner (EC50 6 9 nM) In vascular models A 61603 markedly elevates perfusion pressure demonstrating significantly greater efficacy than noradrenaline This compound serves as a valuable tool for delineating 1A-AR-mediated signaling and vascular regulation
Apexbio Technology LLC BD 1047 dihydrobromide 138356-21-5 10mg
BD 1047 dihydrobromide (CAS 138356-21-5) is a selective antagonist of the sigma-1 ( 1) receptor exhibiting Ki values of 0 93 nM for 1 and 47 nM for sigma-2 ( 2) receptors Sigma receptors distinct from opioid receptors include 1 and 2 subtypes and are implicated in modulating dopaminergic neurotransmission and drug-related behaviors In preclinical models BD 1047 dihydrobromide attenuates haloperidol- and DTG-induced dystonia and reverses cocaine-induced behavioral responses without affecting responses to natural rewards Additionally it alleviates mechanical allodynia in neuropathic pain models and modulates spinal 1 receptor and NR1 subunit expression This compound is utilized to investigate 1 receptor function in neuropharmacology and pain research
Cayman Chemical Clobenpropit hydrobromide
A selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes); reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by (R)-α-methylhistamine at 0.3, 0.1, and 3 nM; decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice at 1 and 3 mg/kg, an effect that can be blocked by (R)-α-methylhistamine or imetit; increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons at 0.1 μM
Apexbio Technology LLC NAN-190 hydrobromide 115338-32-4 10mg
NAN-190 hydrobromide (CAS 115338-32-4) is a selective antagonist of the serotonin 5-HT1A receptor functioning by inhibiting receptor-mediated signal transduction pathways In receptor binding assays NAN-190 hydrobromide demonstrates high affinity for 5-HT1A receptors and modulates neurotransmitter release This compound is frequently employed in neurobiology and psychiatric disorder studies to investigate 5-HT1A-related mechanisms serving as a valuable tool for elucidating serotonergic signaling and its implications in neural function and pathology
Medchemexpress LLC Galanthamine hydrobromide | 1953-04-4 | 99.9% | C17H22BrNO3 | 1 ML
Galanthamine hydrobromide is a selective, reversible, competitive, alkaloid AChE inhibitor (IC50 0.35 μM) and a potent allosteric potentiating ligand (APL) for human α3β4, α4β2, α6β4 nicotinic receptors (nAChRs). It is developed for Alzheimer's disease (AD) research.
- Selective, reversible, competitive, alkaloid AChE inhibitor.
- Potent allosteric potentiating ligand (APL) of human nAChRs.
- Developed for Alzheimer's disease (AD) research.
- Demonstrates 53-fold selectivity for AChE over butyrylcholinesterase.
- Inhibits Aβ 1-40 and Aβ 1-42 aggregation (50 μM).
- Protects against Aβ(1-40) and Aβ(1-42) toxicity in SH-SY5Y cells.
- Reduces Aβ(1-40)-induced cellular apoptosis.
- Reduces cognitive deficits in APP23 mice.
Medchemexpress LLC Dihydro-β-erythroidine hydrobromide | 29734-68-7 | MFCD00153793 | >98.0% | 356.25 g/mol | C16H22BrNO3 | 10 MG
Dihydro-β-erythroidine hydrobromide is a competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs), with selectivity for α4β2 and α4β4 subtypes. It is used as a pharmacological tool in receptor characterization, electrophysiology, and behavioral studies to probe cholinergic signaling.
- Competitive nAChR antagonist selective for α4β2 and α4β4.
- CAS number 29734-68-7.
- Chemical formula C16H22BrNO3; molecular weight 356.25 g/mol.
- Purity >98.0% (HPLC) as reported by catalog vendors.
- Typical research pack sizes: 1 mg, 5 mg, 10 mg.
- Common applications: electrophysiology, receptor pharmacology, and behavioral assays.
Medchemexpress LLC Halofuginone (hydrobromide) | 64924-67-0 | 495.59 | 25 MG
Halofuginone hydrobromide, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor. It specifically inhibits type-I collagen synthesis and helps reduce osteoarthritis by inhibiting TGF-β activity. It also acts as a potent pulmonary vasodilator by activating Kv channels and blocking various Ca2+ channels. This compound exhibits a range of beneficial effects.
- Competitively inhibits prolyl-tRNA synthetase
- Inhibits type-I collagen synthesis
- Attenuates osteoarthritis by inhibiting TGF-β activity
- Potent pulmonary vasodilator
- Activates Kv channels and blocks Ca2+ channels
- Exhibits anti-malaria effects
- Provides anti-inflammatory effects
- Shows anti-cancer activity
- Offers anti-fibrosis effects
- Decreases NRF2 protein levels in tumors
Medchemexpress LLC Guvacoline hydrobrom 5mg | 17210-51-4 | 222.08 g/mol | C7H12BrNO2 | 5 MG
Guvacoline hydrobromide is the hydrobromide salt of guvacoline, a pyridine alkaloid that acts as a weak full agonist of atrial and ileal muscarinic acetylcholine receptors (mAChR). It is supplied as a solid reagent intended for biochemical and pharmacological research applications.
- Hydrobromide salt form suitable for laboratory handling
- CAS number 17210-51-4
- Molecular formula C7H12BrNO2; molecular weight 222.08 g/mol
- Purity 96.09% as verified by certificate of analysis
- Used as a pharmacological tool for muscarinic receptor studies
Medchemexpress LLC Guvacoline hydrobrom 10mg | 17210-51-4 | 222.08 g·mol⁻1 | C7H12BrNO2 | 10 MG
Guvacoline hydrobromide is the hydrobromide salt of guvacoline, a pyridine alkaloid that acts as a weak full agonist at atrial and ileal muscarinic acetylcholine receptors. This research-grade solid is provided for in vitro pharmacology and receptor-binding studies.
- High purity (96.09%) research-grade material.
- Molecular weight 222.08 g·mol⁻1; formula C7H12BrNO2.
- Suitable for muscarinic receptor pharmacology and neuropharmacology assays.
- Supplied as a 10 mg solid for small-scale experimental use.
Medchemexpress LLC Nan-190 hydrobromide | 115338-32-4 | 99.1% | 474.39 | 50 MG
NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.
- Serotonin receptor 5-HT antagonist
- Selective antagonist of 5-HT1A
- IC50 & Target: 5-HT1A Receptor, 5-HT1 Receptor
- Reverses the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats when injected at 0.5 mg/kg (ip) concomitantly with fluoxetine