Hydrochlorides
Medchemexpress LLC RS-127445 hydrochloride | 199864-86-3 | C17H17ClFN3 | 50 MG
RS-127445 hydrochloride is a selective, high-affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. It demonstrates 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites. It is intended for research use only.
- Selective 5-HT2B receptor antagonist
- High-affinity binding
- Orally bioavailable
- Demonstrates 1000-fold selectivity
- Suitable for research applications
Medchemexpress LLC Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- | 893990-34-6 | 99.7% | 342.44 | 25 MG
VU 0240551 is a potent and selective neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM, demonstrating selectivity against NKCC1. It also inhibits hERG and L-type Ca2+ channels. VU 0240551 has been shown to attenuate GABA-induced hyperpolarization of P cells, induce a positive shift in the P cell GABA reversal potential, and enhance P cell synaptic transmission.
- In HEK293 cells, VU 0240551 showed an IC50 of 568 nM for antagonist activity at KCC2.
- It exhibited an IC50 > 50 μM for antagonist activity at NKKC1 in human HEK293 cells.
- VU 0240551 reduces the P cell response to GABA in a concentration-dependent manner.
![Medchemexpress LLC N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide, monohydrochloride | 1309976-62-2 | 98.9% | 330.78 g·mol⁻¹ | C18H16ClFN2O | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000241376.png-250.jpg)
Medchemexpress LLC N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide, monohydrochloride | 1309976-62-2 | 98.9% | 330.78 g·mol⁻¹ | C18H16ClFN2O | 50 MG
VU0360172 hydrochloride is a research-grade small molecule and a potent, selective positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5). Supplied as a solid for in vitro and in vivo pharmacology studies, it is characterized by nanomolar potency and high chemical purity.
- Selective mGlu5 PAM with EC50 = 16 nM and Ki = 195 nM.
- High purity suitable for research use (≈98.9%).
- Solid form, convenient for storage and formulation.
- Molecular weight 330.78 g·mol⁻¹; formula C18H16ClFN2O.
- Recommended sealed storage away from moisture at low temperature.
eMolecules 127168-84-7 | AstaTech | 5-BROMOISOINDOLINE | 0.25g | 222807976 | AB3161 | 95 | MFCD08234718 | 198.063 | C8H8BrN
Ambeed | 4-Fluoro-26-dimethylbenzonitrile | 100mg | 633419216 | A833849 | 14659-61-1 | MFCD04972839 | 149.168 | C9H8FN
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eMolecules BENZYL 1-BENZYL-4-METHYLPIPERAZINE-2-CARBOXYLATE | 1447605-99-3 | MFCD09037846 | 1g
AstaTech | BENZYL 1-BENZYL-4-METHYLPIPERAZINE-2-CARBOXYLATE | 1g | 437210116 | AB2647 | 95.000 | 1447605-99-3 | MFCD09037846 | 324.424 | C20H24N2O2
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Medchemexpress LLC Pazopanib hydrochloride | 635702-64-6 | 100.0% | 100MG
Pazopanib hydrochloride | 635702-64-6 | 100.0% | 100MG