Hydrochlorides

2,5-Diaminotoluene Dihydrochloride 98.0+%, TCI America™

CAS: 615-45-2 Molecular Formula: C7H12Cl2N2 Molecular Weight (g/mol): 195.09 MDL Number: MFCD00035512 InChI Key: VQUHVWVGRKTIBH-UHFFFAOYSA-N Synonym: 2,5-Toluenediamine Dihydrochloride, Tolylene-2,5-diamine Dihydrochloride, 2-Methyl-1,4-phenylenediamine Dihydrochloride PubChem CID: 11996 IUPAC Name: dihydrogen 2-methylbenzene-1,4-diamine dichloride SMILES: [H+].[H+].[Cl-].[Cl-].CC1=CC(N)=CC=C1N

Medchemexpress LLC Icotinib hydrochloride | 1204313-51-8 | C22H22ClN3O4 | 50 MG

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Icotinib Hydrochloride (BPI-2009) is a potent, CNS-penetrant, and specific EGFR inhibitor with an IC50 of 5 nM. It also inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q. This compound functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.

• Potent, CNS-penetrant, and specific EGFR inhibitor
• Inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q
• Has an IC50 of 5 nM for EGFR
• Functions as a click chemistry reagent with an alkyne group
• Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
• Exhibits potent dose-dependent antitumor effects in nude mice
• Blocks EGFR-mediated intracellular tyrosine phosphorylation (IC50=45 nM)
• Well tolerated in mice without significant body weight loss

Medchemexpress LLC 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1160247-92-6 | 99.9% | 10 MG

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VU 0238429 is a selective positive allosteric modulator of the muscarinic acetylcholine receptor subtype M5 (mAChR5), with an EC50 of approximately 1.16 μM. It is used as a research tool to probe M5-mediated GPCR signaling and neuronal pharmacology.

• Molecular formula: C17H12F3NO4.
• Molecular weight: 351.28 g/mol.
• CAS number: 1160247-92-6.
• Purity: ~99.9% by HPLC.
• Solubility: ≥150 mg/mL in DMSO; ≥2.5 mg/mL in 10% DMSO/40% PEG300/5% Tween-80/45% saline for in vivo formulations.
• Target: muscarinic acetylcholine receptor M5 (mAChR5).
• EC50: ~1.16 μM at M5; >30 μM at M1 and M3 indicating selectivity.
• Storage: powder -20°C (long term), 4°C (short term); solutions -80°C (up to 6 months).
• Quantity: supplied as a 10 mg solid.