Lith-O-Asp is a sialyltransferase (ST) inhibitor with IC50s ranging from 12-37 μM. It has been shown to decrease the activity of both a-2,3- and a-2,6-sialyltransferases, inhibiting the transfer of sialic acids to targeted glycoproteins. Research indicates that Lith-O-Asp can suppress FAK/paxillin signaling, as well as cancer angiogenesis and metastasis pathways. It has demonstrated an ability to reduce lung metastases in animal models.
- Sialyltransferase (ST) inhibitor
- IC50s of 12-37 μM
- Suppresses FAK/paxillin signaling
- Inhibits cancer angiogenesis and metastasis pathways
- Decreases activity of a-2,3- and a-2,6-sialyltransferases
- Inhibits transfer of sialic acids to targeted glycoproteins
- Reduces lung metastases in vivo