Lith-O-Asp is a sialyltransferase (ST) inhibitor with IC50 values ranging from 12-37 μM. It has been shown to decrease the activity of both α-2,3- and α-2,6-sialyltransferases, thereby inhibiting the transfer of sialic acids to targeted glycoproteins. Research indicates that Lith-O-Asp may suppress cancer angiogenesis and metastasis pathways, as demonstrated by fewer lung metastases in treated mice compared to controls.
- Sialyltransferase (ST) inhibitor.
- Inhibits the activities of ST3Gal I, ST3Gal III, and ST6GalI.
- Decreases expression of cell surface α-2,3- and α-2,6-sialylated antigens.
- Suppresses cancer angiogenesis and metastasis pathways.