Organic metal halides
Medchemexpress LLC Sepantronium (bromide) | 781600-92-9 | >98% | 750.56 | 25MG
Sepantronium bromide (YM155) is a small molecule inhibitor of survivin, a member of the inhibitor of apoptosis protein (IAP) family. It exhibits potent anticancer activity by suppressing survivin expression, leading to apoptosis in various cancer cell lines.
- Small molecule inhibitor of survivin
- IC50 of 0.54 nM in a cell-free assay
- Potent anticancer activity
- Suppresses survivin expression
- Leads to apoptosis in various cancer cell lines
- Under clinical investigation for the treatment of various cancers
Medchemexpress LLC Tarloxotinib bromide | 1636180-98-7 | 98.75% | 681.77 | 1 ML
Tarloxotinib bromide is an irreversible EGFR/HER2 inhibitor that is efficiently metabolized under hypoxia in human NSCLC cell lines. Cellular anti-proliferative and receptor phosphorylation assays show a 14-80 fold reduction of activity relative to TKI, demonstrating greater activity compared with erlotinib. In vivo studies show that treatment with clinically relevant doses leads to tumor regression and durable inhibition of WT EGFR tumor phosphorylation, and can regress WT EGFR NSCLC tumor models H125 and H1648.
- Irreversible EGFR/HER2 inhibitor
- Efficiently metabolized under hypoxia
- Greater activity compared with erlotinib
- Associated with tumor regression and durable inhibition of WT EGFR tumor phosphorylation
- Can regress WT EGFR NSCLC tumor models H125 and H1648