Organic potassium salts
Medchemexpress LLC N,N'-Dinitrosopiperazine | 140-79-4 | 99.9% | 144.13 | 100 MG
N,N'-Dinitrosopiperazine (DNP) is identified as a carcinogen with specificity for nasopharyngeal epithelium, facilitating nasopharyngeal carcinoma (NPC) metastasis. It regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568.
- Specific carcinogen for nasopharyngeal epithelium
- Facilitates NPC metastasis
- Regulates multiple signaling pathways through protein phosphorylation
- Induces cell invasion and motility in a dose-dependent manner in vitro
- Increases expression of phospho-LYRIC s568 and LYRIC in CNE1 cells
- Promotes NPC metastasis in vivo by inhibiting cell motility and invasion
- Induces LYRIC phosphorylation at serine 568 in vivo
Medchemexpress LLC Sodium oxalate | 62-76-0 | MFCD00012465 | 99.5% | 134.00 g/mol | Na2C2O4 | 5g
Sodium oxalate is an orally active dispersant and coordination agent Sodium oxalate causes mitochondrial dysfunction Sodium oxalate has catalytic enhancing activity Sodium oxalate induces stable chronic kidney disease Sodium oxalate induces highly malignant and undifferentiated breast tumors[1][2][3][4][5][6][7][8]
Medchemexpress LLC Acesulfame (potassium) | 55589-62-3 | 99.4% | 10 G
Acesulfame potassium is a synthetic sweetener that can affect cognitive function by altering neurometabolic functions. It can also suppress autophagic degradation of PD-L1 in cancer cells, which may be related to immune evasion. This product is suitable for research on neurological diseases, metabolic disorders, cancer, and immune evasion.
- Research applications include neurological diseases, metabolic disorders, cancer, and immune evasion.
- Upregulates PD-L1 protein levels in RIL-175 and SK-Hep1 cells.
- Increases granzyme B production in co-cultured T cells.
- Activates ERK1/2-mTORC1-ULK1 pathway to suppress autophagic degradation of PD-L1.
- Inhibits mitochondrial metabolism and impairs neuroprotective functions in SH-SY5Y cells.
- Affects body weight and gut microbiome composition in male CD-1 mice.
- Alters neurometabolic functions in C57BL/6J mice.
Medchemexpress LLC N,N'-Dinitrosopiperazine | 140-79-4 | 99.9% | 144.13 | 50 MG
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is identified as a carcinogen that specifically targets the nasopharyngeal epithelium and contributes to nasopharyngeal carcinoma (NPC) metastasis. It influences various signaling pathways through protein phosphorylation, including LYRIC at serine 568.
- Does not inhibit 6-10B cells at lower concentrations (0-8 μm)
- Exhibits cytotoxicity from 10 μm upwards
- Enhances 6-10B cell invasion and motility in a dose-dependent manner (2-8 μm)
- Increases cell invasion by 421.7% and motility by 328.2% at 6 μm
- Upregulates phospho-LYRIC s568 and LYRIC expression in CNE1 cells
- Inhibits cell motility and invasion in vivo at 40 mg/kg
- Facilitates NPC metastasis in vivo at 40 mg/kg
- Shows higher phospho-LYRIC expression in metastatic tumors in DNP-treated mice
Medchemexpress LLC Acesulfame potassium (Standard) | 55589-62-3 | MFCD00043833 | 99.9% | 50 MG
Acesulfame potassium (Standard) is the analytical standard of Acesulfame potassium, intended for research and analytical applications. This artificial sweetener has been observed to affect cognitive functions, potentially via altering neuro-metabolic functions in mice. It serves as a reference standard for assay and is of analytical grade.
- Used as a reference standard supplied assay
- Commonly used in qualitative research experiments
- Commonly used in quantitative research experiments
- Commonly used in methodological research experiments
- Suitable for HPLC
- Suitable for GC
- Suitable for MS
Medchemexpress LLC Naloxegol oxalate | 1354744-91-4 | 99.9% | C36H55NO15 | 50 MG
Naloxegol oxalate is an orally active, peripherally acting μ-opioid receptor antagonist. It works by inhibiting the binding of opioids to μ-opioid receptors in the gastrointestinal tract, thereby alleviating opioid-induced conditions like hypomotility, delayed transit, hypertonicity, and increased fluid reabsorption. This compound is primarily used in research related to opioid-induced constipation.
- Orally active, peripherally acting μ-opioid receptor antagonist
- Inhibits opioid binding in the gastrointestinal tract
- Alleviates opioid-induced gastrointestinal hypomotility
- Used in research for opioid-induced constipation
- Binds with high affinity to μ-opioid and κ-opioid receptors
- Shows low affinity to δ-opioid receptors with no significant activity at non-opioid targets
Medchemexpress LLC Ldn-211904 oxalate | 1198408-78-4 | MFCD28023573 | 99.0% | 444.87 g·mol⁻¹ | C21H21ClN4O5 | 1 ML
LDN-211904 oxalate is the oxalate salt of a potent, reversible EphB3 kinase inhibitor supplied for in vitro biochemical and cellular research. Available as solid material and as a ready-to-use DMSO stock solution, it includes manufacturer guidance for solubility and storage to support assay development.
- Potent and reversible EphB3 inhibitor with low-nanomolar activity.
- High chemical purity: 99.0%.
- Molecular weight 444.87 g·mol⁻1 and formula C21H21ClN4O5.
- Available as solid (1 mg, 5 mg, 10 mg) and prepared DMSO stock (10 mM in 1 mL).
- Soluble ≥ 2.5 mg/mL (approximately 5.62 mM) in 10% DMSO and compatible vehicles.
- Storage guidance: -20°C sealed; in solvent -80°C up to 6 months.
Medchemexpress LLC Naloxegol oxalate | 1354744-91-4 | 99.9% | C36H55NO15 | 1 ML
Naloxegol oxalate | 1354744-91-4 | 99.9% | C36H55NO15 | 1 ML
Cayman Chemical Acesulfame-d4potasIum salt 1mg
An internal standard for the quantification of acesulfame by GC- or LC-MS
Medchemexpress LLC Acesulfame potassium | 55589-62-3 | 99.38% | 5 G
Acesulfame potassium is a synthetic sweetener that can affect cognitive function and may be related to immune evasion in cancer cells by suppressing autophagic degradation of PD-L1. It is for research use only and suitable for studies on neurological diseases, metabolic disorders, cancer, and immune evasion.
- Upregulates PD-L1 protein levels in RIL-175 and SK-Hep1 cells.
- Increases granzyme B production in RIL-175 and SK-Hep1 cells co-cultured with T cells.
- Activates ERK1/2-mTORC1-ULK1 pathway to suppress autophagic degradation of PD-L1.
- Inhibits mitochondrial metabolism and ATP production in SH-SY5Y cells.
- Impairs energy metabolism and neuroprotective functions.
- Increases body weight in male CD-1 mice and alters gut microbiome.
- Affects neurometabolic functions in C57BL/6J mice with long-term intake.
Apexbio Technology LLC Malachite green oxalate 2437-29-8 100mg
Malachite green oxalate (CAS 2437-29-8) is a triphenylmethane dye commonly utilized for quantifying phosphate release in enzymatic assays Mechanistically it functions as a selective inhibitor of IKBKE kinase resulting in reduced phosphorylation and activity of downstream effectors including I B p65 and IRF3 Experimental studies have demonstrated its ability to suppress tumor cell proliferation and interfere with related signaling pathways in various cell lines and animal models Malachite green oxalate serves as a valuable tool for investigating tumorigenic mechanisms and exploring targeted therapeutic strategies
eMolecules 95-92-1 | Diethyl oxalate | Combi-Blocks | MFCD00009119 | 146.142 | C6H10O4 | 98.000 | CCOC(=O)C(=O)OCC | 25g | 296394160
Diethyl oxalate | Combi-Blocks | 95-92-1 | MFCD00009119 | 146.142 | C6H10O4 | 98.000 | CCOC(=O)C(=O)OCC | 25g | 296394160
Strem, An Ascensus Company CAS# 34171-69-2. 1g. Potassium tricyanomethanide, min. 98%. MFCD00058850
CAS# 34171-69-2. 1g. Potassium tricyanomethanide, min. 98%. MFCD00058850. Molecular Weight: 129.16. Molecular Formula: KC(CN)3. Color/form: off-white to beige pwdr. Strem# 06-1700. http://www.strem.com/catalog/v/06-1700/
