Sulfonyl halides
Medchemexpress LLC Amg-1694 | 1361217-07-3 | 533.63 | 25 MG
AMG-1694 is a potent glucokinase-glucokinase regulatory protein (GK-GKRP) disruptor. It promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, thereby indirectly increasing GK enzymatic activity. It effectively reverses the inhibitory effect of GKRP on GK activity and encourages GK translocation. In various rodent models of diabetes, AMG-1694 normalizes blood glucose levels, with its effect restricted to diabetic animals and not observed in normoglycemic ones.
- IC50 & target: 7 nM (GK-GKRP)
- Hepatocyte EC50: 0.082 μM (inhibition of GKRP-GK interaction in rat primary hepatocytes)
- Hepatocyte EC50: 1.79 μM (induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes)
- In vitro: Effectively restores the enzymatic activity of GK with an EC50 of 0.020 μM in the presence of GKRP
eMolecules 4-Methanesulfonyl-3-(morpholin-4-yl)aniline | 942474-45-5 | MFCD09027709 | 1g
Combi-Blocks | 4-Methanesulfonyl-3-(morpholin-4-yl)aniline | 1g | 232301405 | AN-3360 | 97.000 | 942474-45-5 | MFCD09027709 | 256.320 | C11H16N2O3S
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eMolecules 2-CYCLOPROPYLACETYL CHLORIDE | 54322-65-5 | MFCD11110393 | 1g
AstaTech | 2-CYCLOPROPYLACETYL CHLORIDE | 1g | 454130285 | P19146 | 95.000 | 54322-65-5 | MFCD11110393 | 118.560 | C5H7ClO
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eMolecules 2-Methanesulfonyl-4-nitroaniline | 96-74-2 | MFCD00044068 | 1g
Combi-Blocks | 2-Methanesulfonyl-4-nitroaniline | 1g | 303330829 | LD-1362 | 98.000 | 96-74-2 | MFCD00044068 | 216.210 | C7H8N2O4S
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eMolecules 4-(4-Methanesulfonyl-phenyl)-piperidine | 885274-65-7 | MFCD04114999 | 5g
J & W PharmLab, LLC | 4-(4-Methanesulfonyl-phenyl)-piperidine | 5g | 249984827 | 60R0116 | 95.000 | 885274-65-7 | MFCD04114999 | 239.330 | C12H17NO2S
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eMolecules 2-Methanesulfonyl-5-methoxy-benzylamine | 1192369-26-8 | MFCD28098098 | 5g
J & W PharmLab, LLC | 2-Methanesulfonyl-5-methoxy-benzylamine | 5g | 249977504 | 20R1476 | 98.000 | 1192369-26-8 | MFCD28098098 | 215.270 | C9H13NO3S
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eMolecules 3-Bromo-5-(1,3,4-oxadiazol-2-yl)pyridine | 924869-13-6 | MFCD08444031 | 500mg
Matrix Scientific | 3-Bromo-5-(1,3,4-oxadiazol-2-yl)pyridine | 500mg | 389721452 | 46870 | 95.000 | 924869-13-6 | MFCD08444031 | 226.033 | C7H4BrN3O
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eMolecules 1-(4-methylbenzenesulfonyl)azetidin-3-one | 76543-27-6 | MFCD00129860 | 25g
Pharmablock | 1-(4-methylbenzenesulfonyl)azetidin-3-one | 25g | 551271616 | PBN20121417 | | 76543-27-6 | MFCD00129860 | 225.260 | C10H11NO3S
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Matrix Scientific 4-BROMO-2-FLUOROBENZENESULF-5G
4-Bromo-2-fluorobenzenesulfonyl chloride, 98%; 5g,C6H3BrClFO2S, MFCD01090993, mw 273.51, [216159-03-4]
eMolecules Ambeed / 2-Methoxy-5-nitrobenzene-1-sulfonyl chloride / 100mg / 628568513 / A695338 / / 81118-92-5 / MFCD07343894 / 251.640 / C7H6ClNO5S
Ambeed / 2-Methoxy-5-nitrobenzene-1-sulfonyl chloride / 100mg / 628568513 / A695338 / / 81118-92-5 / MFCD07343894 / 251.640 / C7H6ClNO5S
eMolecules Pharmablock cyclopropanesulfonyl chloride 50mg 551151408 PBTEN0254 0 000 139631-62-2 MFCD01631933 140 580 C3H5ClO2S
Pharmablock cyclopropanesulfonyl chloride 50mg 551151408 PBTEN0254 0 000 139631-62-2 MFCD01631933 140 580 C3H5ClO2S
eMolecules BENZENESULFONYL CHLORIDE, 2-FLUORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)- | 1003575-37-8 | MFCD22493932 | 1g
AstaTech | BENZENESULFONYL CHLORIDE, 2-FLUORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)- | 1g | 338842229 | P17018 | 95.000 | 1003575-37-8 | MFCD22493932 | 320.570 | C12H15BClFO4S
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eMolecules 1-(3-Bromo-1-benzofuran-2-yl)-1-ethanone | 99661-02-6 | MFCD09972223 | 1g
Matrix Scientific | 1-(3-Bromo-1-benzofuran-2-yl)-1-ethanone | 1g | 389721313 | 46207 | 95.000 | 99661-02-6 | MFCD09972223 | 239.068 | C10H7BrO2
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eMolecules Pharmablock cyclopropanesulfonyl chloride 100mg 551151409 PBTEN0254 0 000 139631-62-2 MFCD01631933 140 580 C3H5ClO2S
Pharmablock cyclopropanesulfonyl chloride 100mg 551151409 PBTEN0254 0 000 139631-62-2 MFCD01631933 140 580 C3H5ClO2S
Bachem Phenylmethylsulfonyl fluoride
Phenylmethylsulfonyl fluoride, 329-98-6, C7H7FO2S, Mr 174.20, 25g. PMSF, Pms-F. PMSF inhibits serine proteases such as trypsin and chymotrypsin, cysteine proteases such as papain, and acetylcholinesterase.