This compound is a research-grade small-molecule inhibitor of aldo-keto reductase 1C3 (AKR1C3) that selectively blocks AKR1C3-mediated reduction of doxorubicin and can reverse doxorubicin resistance in AKR1C3-overexpressing cells. Supplied as a high-purity solid, it is intended for biochemical and cellular research applications.
- Target: AKR1C3 inhibitor.
- Mechanism: selectively blocks AKR1C3-mediated reduction of doxorubicin.
- Purity: 99.5% (reported value).
- Physical form: white to off-white solid.
- Solubility: soluble in DMSO (≈100 mg/mL); in vivo formulations reported in DMSO/corn oil.
- Storage: powder stable at -20°C for long-term storage; solutions require low-temperature storage.