Dimethyl Sulfoxide
Apexbio Technology LLC Valganciclovir HCl 175865-59-5 10mM (in 1mL DMSO)
Valganciclovir hydrochloride is an antiviral prodrug that undergoes rapid enzymatic conversion to the active metabolite ganciclovir after oral administration Ganciclovir inhibits viral replication by selectively targeting viral DNA polymerase thereby interfering with viral DNA synthesis and slowing cytomegalovirus (CMV) proliferation Valganciclovir is commonly utilized in laboratory studies to evaluate antiviral activity against CMV and related herpesviruses and to investigate its therapeutic potential in CMV-associated infections including retinitis and organ transplant-associated CMV infections In vitro studies report an IC50 value for valganciclovir-derived ganciclovir ranging approximately from 0 2 to 2 8 M depending on experimental cell type and viral strain
Apexbio Technology LLC Simeprevir(Synonyms: Olysio, TMC435, TMC435350, Simeprevir sodium), 10mM (in 1mL DMSO), CAS: 923604-59-5.
Simeprevir (CAS 923604-59-5) is a small molecule inhibitor targeting the hepatitis C virus (HCV) NS3/4A protease a viral serine protease essential for viral polyprotein processing and replication Simeprevir inhibits NS3/4A protease with a Ki of 0 36 nM and demonstrates antiviral activity by reducing viral replication in Huh-7 replicon cells (EC50 of 7 8 nM) and Huh7-Luc HCV genotype 1b replicon cells (EC50 of 8 nM EC90 of 24 nM) Simeprevir is widely utilized in research on antiviral mechanisms and therapeutic strategies against HCV infections
Apexbio Technology LLC Atomoxetine HCl 82248-59-7 10mM (in 1mL DMSO)
Atomoxetine HCl (CAS 82248-59-7) is a selective inhibitor of the norepinephrine transporter (NET) a membrane protein responsible for norepinephrine reuptake and synaptic homeostasis Atomoxetine shows high selectivity towards human NET (Ki 5 nM) with substantially lower affinity for serotonin (Ki 77 nM) and dopamine transporters (Ki 1451 nM) In preclinical studies using rat models atomoxetine elevated extracellular norepinephrine and dopamine specifically in the prefrontal cortex region without affecting dopamine levels in the striatum or nucleus accumbens These traits render it useful in research on neurotransmitter regulation related to cognition and attention disorders