Dimethyl Sulfoxide
Apexbio Technology LLC YO-01027 (Dibenzazepine, DBZ) 209984-56-5 10mM (in 1mL DMSO)
YO-01027 (Dibenzazepine DBZ CAS 209984-56-5) is a potent inhibitor targeting -secretase a multimeric aspartyl protease involved in the proteolytic cleavage of type I integral membrane proteins notably amyloid precursor protein-like (APPL) proteins and Notch receptors YO-01027 interacts with the N-terminal regions of presenilin dose-dependently inhibiting cleavage of APPL and Notch proteins Research indicates that YO-01027 modulates cell differentiation by suppressing Notch signaling pathways influencing cellular transitions and mucin (MUC16) synthesis illustrating its utility in cell biology and therapeutic studies of Notch-related signaling processes
Apexbio Technology LLC BI6727 (Volasertib)(Synonyms: Volasertib, BI-6727, BI 6727, Plk inhibitor BI6727, Polo-like kinase inhibitor BI6727), 10mM (in 1mL DMSO), CAS: 755038-65-4.
BI6727 (Volasertib CAS 755038-65-4) is a selective inhibitor of Polo-like kinases (Plk) primarily targeting Plk1 with an IC50 of 0 87 nM and showing lower potency towards Plk2 (IC50 5 nM) and Plk3 (IC50 56 nM) Plk1 regulates the G2/M cell cycle transition and is commonly overexpressed in various tumor types representing a potential therapeutic target BI6727 inhibits proliferation across multiple tumor cell lines including colorectal (HCT116 EC50 23 nM) lung (NCI-H460 EC50 21 nM) melanoma (BRO EC50 11 nM) and hematologic cancer (GRANTA EC50 15 nM) In vivo BI6727 administration induced apoptosis and reduced tumor growth in mouse HCT116 and NCI-H460 xenograft models