Dimethyl Sulfoxide
Apexbio Technology LLC Griseofulvin 126-07-8 10mM (in 1mL DMSO)
Griseofulvin is an antifungal antibiotic known to inhibit fungal growth by interfering with microtubule polymerization thereby disrupting mitotic spindle formation and cellular division Through binding to tubulin it stabilizes microtubule structures preventing their normal assembly and leading to impaired fungal cell replication Experimentally Griseofulvin has been frequently utilized to study microtubule dynamics mitotic processes and antifungal mechanisms in research settings involving medically relevant fungi including dermatophytes Reported IC50 values for Griseofulvin range approximately from 5 to 20 M depending on fungal strains and conditions tested serving as a guideline for establishing antifungal assays and investigating fungal response mechanisms in vitro
Apexbio Technology LLC Darifenacin HBr 133099-07-7 10mM (in 1mL DMSO)
Darifenacin HBr (CAS 133099-07-7) known as UK88525 is a selective antagonist of the M3 muscarinic acetylcholine receptor (mAChR M3) It demonstrates high binding affinity (pKi 8 9) toward M3 receptors which mediate smooth muscle contraction and glandular secretion in various tissues In vitro studies reveal that darifenacin acts as a substrate of the P-gp efflux transporter at the blood-brain and blood-ocular barriers In animal models darifenacin modulates bladder contractility and reduces bladder afferent nerve activity Clinically it is employed in research focusing on disorders involving abnormal detrusor muscle activity such as overactive bladder syndrome