Dimethyl Sulfoxide
Apexbio Technology LLC IWR-1-endo 1127442-82-3 10mM (in 1mL DMSO)
IWR-1-endo (CAS 1127442-82-3) is a synthetic small-molecule antagonist of the Wnt/ -catenin signaling pathway It inhibits the activity of WNT1 2 and 3 ligands preventing downstream -catenin accumulation by stabilizing Axin-based degradation complexes and disrupting signaling events mediated via LRP6 and DVL2 Experimentally IWR-1-endo suppresses processes dependent on Wnt/ -catenin activity such as tissue regeneration and epithelial stem cell self-renewal demonstrated notably in zebrafish tailfin regeneration models Additionally it reduces abnormal proliferation induced by APC loss in cancer cell lines highlighting its relevance in oncogenesis research
Apexbio Technology LLC Mitoxantrone HCl(Synonyms: Mitoxantrone hydrochloride, Novantrone, DHAD, Mitoxantrone HCl, Mitoxantrone dihydrochloride), 10mM (in 1mL DMSO), CAS: 70476-82-3.
Mitoxantrone HCl (CAS 70476-82-3) is an antineoplastic small molecule inhibitor targeting DNA topoisomerase II (Topo-II) Topo-II enzymes manage DNA topology during replication and transcription facilitating chromosome segregation and relieving torsional stress Mitoxantrone interferes with Topo-II-mediated DNA cleavage and ligation inducing double-strand DNA breaks and chromatin rearrangement thus disrupting DNA synthesis and cell cycle progression It modulates activity of immune cells including T cells B cells and macrophages Research demonstrates mitoxantrone s apoptotic or senescence-inducing effects in normal human cell models Its uses in biomedical research include studies on leukemia multiple sclerosis and pancreatic cancer cell viability
Apexbio Technology LLC PF-543 1415562-82-1 10mM (in 1mL DMSO)
PF-543 (CAS 1415562-82-1) is a cell-permeable inhibitor targeting sphingosine kinase 1 (SphK1) an enzyme that phosphorylates sphingosine to sphingosine-1-phosphate (S1P) It displays potent inhibitory activity against SphK1 with an IC50 of 3 6 nM through sphingosine-competitive (non-ATP competitive) binding Treatment of SphK1-overexpressing head and neck cancer (1483) cells led to a ten-fold decrease in S1P levels confirming effective target engagement PF-543 is widely utilized as a research tool in studies investigating SphK1-mediated signaling pathways in cancer biology and immune cell trafficking
Apexbio Technology LLC CAL-101 (Idelalisib, GS-1101) 870281-82-6 10mM (in 1mL DMSO)
CAL-101 (Idelalisib GS-1101 CAS 870281-82-6) is a selective inhibitor targeting the p110 isoform of phosphatidylinositol 3-kinase (PI3K) an enzyme involved in signaling pathways critical for proliferation and survival of malignant B cells By inhibiting PI3K p110 CAL-101 reduces PI3K-mediated phosphorylation of Akt and other downstream factors leading to enhanced PARP cleavage and caspase activation ultimately inducing apoptosis in malignant B cells CAL-101 has been demonstrated to counteract survival signals initiated by molecules such as CD40 ligand (CD40L) TNF- and fibronectin This agent is valuable in investigating B-cell malignancies
Apexbio Technology LLC BQU57 1637739-82-2 10mM (in 1mL DMSO)
BQU57 (CAS 1637739-82-2) is a small-molecule inhibitor derived from RBC8 selectively targeting the GDP-bound form of the Ral GTPases BQU57 binds preferentially to RalB-GDP exhibiting measured dissociation constants (Kd) of approximately 7 7 M (ITC) and 4 7 M (SPR) In vitro assays using cell lines such as H2122 and H358 have shown suppression of Ral-dependent anchorage-independent colony formation at IC50 values of 2 0 M and 1 3 M respectively In mouse xenograft tumor models administration of BQU57 resulted in reduced activation of RalA and RalB without affecting Ras or RhoA signaling highlighting its utility as a tool compound for investigating Ral-driven tumor biology