Dimethyl Sulfoxide
Apexbio Technology LLC TMP269 1314890-29-3 10mM (in 1mL DMSO)
TMP269 (CAS 1314890-29-3) is a selective inhibitor of class IIa histone deacetylases (HDACs) specifically targeting HDAC isoforms 4 5 7 and 9 with IC50 values of 126 80 36 and 9 nM respectively HDACs catalyze removal of acetyl groups from histone lysine residues thereby condensing chromatin and repressing transcription TMP269 induces moderate cytotoxicity (IC50 22-38 M) in multiple myeloma cell lines correlating with cleavage of caspase-3 -8 -9 and PARP and enhances ER stress-induced apoptosis signaling pathways Additionally TMP269 inhibits PKD1-mediated proliferation in intestinal epithelial IEC-18 cells
Apexbio Technology LLC Moclobemide (Ro 111163) 71320-77-9 10mM (in 1mL DMSO)
Moclobemide (Ro 111163 CAS 71320-77-9) is a reversible inhibitor of monoamine oxidase A (MAO-A) with a reported IC50 of approximately 10 M In vitro studies using rat brain homogenate indicate that it selectively targets MAO-A over MAO-B though with moderate potency Animal experiments demonstrate up to 80% inhibition of MAO-A activity in brain and liver tissues upon administration Prolonged high-dose exposure to Moclobemide alters adrenergic receptor profiles by downregulating -adrenergic receptors and enhancing affinity of 1-adrenergic agonist binding Due to its MAO-A specificity this compound serves as a prototype reversible inhibitor (RIMA) with relevance in antidepressant drug research