Dimethyl Sulfoxide
Apexbio Technology LLC AZD6244 (Selumetinib) 606143-52-6 10mM (in 1mL DMSO)
AZD6244 (Selumetinib CAS 606143-52-6) is a small-molecule inhibitor selectively targeting MEK1/2 components of the MAP kinase signaling cascade It inhibits MEK1 via a non-ATP-competitive mechanism with an IC50 of 14 1 nM leading to decreased phosphorylation of downstream targets ERK1/2 (IC50 10 3 nM cellular assays) AZD6244 exhibits minimal off-target activity against related kinases including MKK6 EGFR ErbB2 and B-Raf In tumor cell lines harboring activated Ras or B-Raf mutations AZD6244 reduces cell proliferation and inhibits growth in xenograft models Thus AZD6244 is useful for investigating MAP kinase pathway-driven malignancies
Apexbio Technology LLC Pazopanib (GW-786034) 444731-52-6 10mM (in 1mL DMSO)
Pazopanib (GW-786034 CAS 444731-52-6) is a second-generation multitargeted receptor tyrosine kinase inhibitor selectively targeting vascular endothelial growth factor receptors (VEGFR) platelet-derived growth factor receptors (PDGFR) and c-kit Through blockade of these kinase activities pazopanib suppresses signaling cascades essential for angiogenesis and cellular proliferation Preclinical tumor models indicate that pazopanib alone or combined with chemotherapy demonstrates substantial anti-angiogenic and antitumor efficacy Its distinct inhibitory profile of intracellular VEGFR tyrosine kinases offers valuable applications in oncology research particularly in investigating angiogenesis-driven signaling pathways
Apexbio Technology LLC URB597(Synonyms: URB-597, KDS-4103, FAAH inhibitor URB597, Cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester), 10mM (in 1mL DMSO), CAS: 546141-08-6.
URB597 (CAS 546141-08-6) also known as KDS-4103 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH) an enzyme responsible for intracellular hydrolysis of the endocannabinoid anandamide In vitro assays indicate that URB597 inhibits FAAH activity with IC values of 3 nM in human liver microsomes and 52 nM in rat brain membranes Intraperitoneal administration in rats results in FAAH inhibition within brain tissue (ID 0 15 mg/kg) URB597 exhibits minimal interaction with cannabinoid receptors anandamide transporters or other related receptors ion channels enzymes and transporters This selectivity makes URB597 valuable for investigating endocannabinoid signaling pathways in biomedical research
Apexbio Technology LLC Rocilinostat (ACY-1215) 1316214-52-4 10mM (in 1mL DMSO)
Rocilinostat (ACY-1215 CAS 1316214-52-4) is a selective inhibitor of histone deacetylase 6 (HDAC6) HDAC6 enzymatically regulates various cellular processes including protein trafficking cell-cycle progression and cytoskeletal organization and its dysregulated activity is implicated in tumor progression and cancer metastasis Rocilinostat potently inhibits HDAC6 (IC50 5 nM) while showing minimal activity against other HDAC isoforms and sirtuins (IC50 1 M) Preclinical studies using multiple myeloma (MM) cell lines and xenograft mouse models demonstrated rocilinostat can enhance acetylation of -tubulin disrupt protein stability pathways and sensitize cancer cells to proteasome inhibitors such as bortezomib and carfilzomib resulting in increased apoptosis and reduction in tumor growth