Dimethyl Sulfoxide
Apexbio Technology LLC LY2835219 1231930-82-7 10mM (in 1mL DMSO)
LY2835219 (CAS 1231930-82-7) is a selective orally bioavailable inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) It targets CDK4 and CDK6 with reported IC50 values of 2 nM and 10 nM respectively thereby reducing phosphorylation of the retinoblastoma protein (Rb) This mechanism leads to cell-cycle arrest during the G1 phase and subsequent inhibition of tumor cell proliferation LY2835219 demonstrates the capacity to cross the blood-brain barrier indicating its potential utility in research involving primary or metastatic intracranial tumors
Apexbio Technology LLC BQU57 1637739-82-2 10mM (in 1mL DMSO)
BQU57 (CAS 1637739-82-2) is a small-molecule inhibitor derived from RBC8 selectively targeting the GDP-bound form of the Ral GTPases BQU57 binds preferentially to RalB-GDP exhibiting measured dissociation constants (Kd) of approximately 7 7 M (ITC) and 4 7 M (SPR) In vitro assays using cell lines such as H2122 and H358 have shown suppression of Ral-dependent anchorage-independent colony formation at IC50 values of 2 0 M and 1 3 M respectively In mouse xenograft tumor models administration of BQU57 resulted in reduced activation of RalA and RalB without affecting Ras or RhoA signaling highlighting its utility as a tool compound for investigating Ral-driven tumor biology