Dimethyl Sulfoxide
Apexbio Technology LLC Mocetinostat (MGCD0103, MG0103) 726169-73-9 10mM (in 1mL DMSO)
Mocetinostat (MGCD0103 MG0103 CAS 726169-73-9) is an isotype-selective inhibitor of human histone deacetylases (HDACs) It selectively targets class I HDAC enzymes (HDAC1 HDAC2 HDAC3) and class IV HDAC11 without affecting class II HDACs Mocetinostat inhibits these isoforms with IC50 values of 0 15 mol/L (HDAC1) 0 29 mol/L (HDAC2) 1 66 mol/L (HDAC3) and 0 59 mol/L (HDAC11) resulting in histone hyperacetylation cell cycle arrest and apoptosis in various cancer cell lines It serves as a research tool for studying epigenetic regulation and as a candidate compound for anticancer drug development
Apexbio Technology LLC PTC-209 315704-66-6 10mM (in 1mL DMSO)
PTC-209 (CAS 315704-66-6) is a small-molecule inhibitor targeting BMI-1 identified through Gene Expression Modulation by Small molecules (GEMS) technology It acts by suppressing BMI-1 expression at the transcriptional level displaying an IC50 of approximately 0 5 M In HCT116 cells PTC-209 reduces both UTR-mediated and endogenous BMI-1 expression It selectively restricts cell proliferation in certain tumor and stem cell types including U937 HT1080 and human hematopoietic stem cells without affecting viability in cell lines such as HEK293 and HT1080 Thus PTC-209 is primarily utilized in studies exploring cancer stem cell growth and oncogenesis involving BMI-1 and the PRC1 complex