Tetrahydrofuran

Medchemexpress LLC 2-((5-((4-fluorophenyl)carbamoyl)pyrimidinyl)sulfanylmethyl)-4-(trifluoromethoxy)phenyl boronic acid | 1648843-04-2 | 98.7% | 25 MG

SX-682 (CAS 1648843-04-2) is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 investigated for oncology research. It blocks recruitment of immunosuppressive myeloid-derived suppressor cells to the tumor microenvironment and can enhance the activity of checkpoint inhibitors.

• Oral bioavailability and potent CXCR1/2 antagonism
• Useful for preclinical and clinical oncology research
• Blocks myeloid-derived suppressor cell recruitment to tumors
• Well-characterized chemical identity: CAS 1648843-04-2, C19H14BF4N3O4S
• Analytical purity typically >98% and supplied as a 25 MG vial

Medchemexpress LLC 2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl boronic acid | 1648843-04-2 | 99.7% | 10 MG

SX-682 is an orally bioavailable small-molecule allosteric inhibitor of chemokine receptors CXCR1 and CXCR2 under clinical investigation for oncology indications; it blocks recruitment of myeloid-derived suppressor cells and can enhance T-cell activity.

• Orally bioavailable small-molecule CXCR1/2 inhibitor
• Blocks recruitment of myeloid-derived suppressor cells (MDSCs)
• Enhances T-cell activation and antitumor immune responses
• Demonstrated activity in preclinical tumor models and clinical trials
• Supplied with high purity (typical >99%) and available in small-mass packaging for research