Organic Acids
Medchemexpress LLC Api137 TFA | 1428789-03-0 | 2291.71 | 1 MG
Api137 is an antimicrobial peptide designed to interfere with bacterial growth by inhibiting translation. It achieves this by trapping release factors on the 70S ribosome after the nascent polypeptide chain has been hydrolyzed, thereby preventing protein synthesis.
- Antimicrobial activity: effectively interferes with bacterial growth
- Translation inhibition: specific action on protein synthesis by targeting ribosomal release factors
- Research use only: intended for research purposes
- TFA form availability: available in a TFA (trifluoroacetate) form
Medchemexpress LLC Crotamine TFA | 98.06% | 4883.73 (free base) | 1 MG
Crotamine TFA is a Na+ channel modulator, a 42 amino acid toxin cross-linked by three disulfide bridges. It exhibits analgesic activity and interacts with lipid membranes, showing myonecrotic activity. It can be isolated from *Crotalus durissus terrificus* venom.
- Na+ channel modulator
- 42 amino acid toxin
- Cross-linked by three disulfide bridges
- Analgesic activity
- Interacts with lipid membranes, showing myonecrotic activity
Medchemexpress LLC Norleual TFA | 6404-28-0 | >99.9% | 888.97 | 5 MG
Norleual TFA is an angiotensin (Ang) IV analog and a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. It also functions as an AT4 receptor antagonist and demonstrates potent antiangiogenic activities.
- Reduces HGF-dependent c-Met and Gab1 phosphorylation
- Attenuates HGF-initiated association between Gab1 and c-Met
- Inhibits HGF-dependent c-Met activation and downstream signaling
- Inhibits HGF-dependent signaling, proliferation, migration, and invasion
- Suppresses pulmonary colonization by B16-F10 murine melanoma cells
Medchemexpress LLC LL-37, human TFA | 154947-66-7 | 100.0% | 4493.26 | 5 MG
LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide. It demonstrates a broad spectrum of antimicrobial activity.
- Exhibits broad-spectrum antimicrobial activity.
- May help protect the cornea from infection.
- Modulates wound healing.
Medchemexpress LLC Astressin 2B TFA | 99.54% | 4041.69 | 500 UG
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist. It blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin-induced hemorrhagic intestinal injury in rats. It also reverses the protective effects of Urocortin 1 and attenuates stress-induced anxiety-related behaviors. This product is a valuable tool for investigating the intestinal protective mechanisms of CRFR2.
- Highly selective CRFR2 antagonist (IC50=0.57 nM).
- Blood-brain barrier-impermeable.
- Exacerbates indomethacin-induced hemorrhagic intestinal injury.
- Reverses protective effects of urocortin 1.
- Attenuates stress-induced anxiety-related behaviors.
- Valuable tool for studying CRFR2 intestinal protective mechanisms.
Medchemexpress LLC Pemvidutide (TFA) | 2538014-94-5 | 98.1% | C182H275N39O54.xC2HF3O2 | 25 MG
Pemvidutide TFA (ALT-801) is a GLP-1R/GCGR dual agonist that causes significant reductions in body weight, liver fat, and serum lipids. It is used in non-alcoholic steatohepatitis (NASH) and obesity research.
- Causes striking reductions in body weight, liver fat, and serum lipids
- Applicable for research in non-alcoholic steatohepatitis (NASH) and obesity
- Improved NASH outcomes in C57BL6/J mice
- Lowered hepatic lipids
- Lowered liver weight
- Reduced biomarkers of liver injury (plasma ALT and AST)
- Decreased the inflammation marker galactin-3
- Reduced the fibrosis marker Col1a1
- Lowered the NAS score