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Organic compounds in which a hydrogen atom or more has been replaced by a halogen atom in an alkane molecule (saturated hydrocarbon chain). Halogen atoms include bromine, chlorine, fluorine, and iodine. Compounds may be in closed ring configurations.
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360A iodide (CAS 737763-37-0) is a 2 6-pyridine-dicarboxamide derivative that acts as a selective ligand for G-quadruplex DNA structures By stabilizing telomeric G-quadruplexes 360A inhibits telomerase activity and induces alterations in cell cycle progression notably causing S-phase accumulation in ATM-proficient EBV-lymphocytes Its mechanism of action involves promoting sister telomere fusions via DNA-PKcs-dependent non-homologous end joining (NHEJ) as well as triggering NHEJ and homologous recombination (HR) pathways at telomeres which disrupt mitotic progression 360A has been shown to preferentially bind telomeric G-quadruplex DNA over duplex DNA and to delay growth in HT1080 tumor cells This compound is valuable for investigating telomere biology DNA damage response and G-quadruplex-mediated genomic stability
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MK-4101 is a small-molecule Smoothened (SMO) antagonist and hedgehog pathway inhibitor used for research applications, including in vitro pathway studies and preclinical cancer research. It shows antitumor activity by inhibiting tumor cell proliferation and inducing apoptosis.
Small-molecule SMO antagonist suitable for in vitro and preclinical studies.
High reported purity of 99.16%.
Molecular weight 493.47 g/mol and formula C24H24F5N5O.
Soluble in DMSO at ≥50 mg/mL; in vivo formulation protocols available.
Recommended storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years).
Reported cellular potency in the low micromolar range (IC50 values).
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Also available in 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Isopropamide iodide is a long-acting anticholinergic drug used for peptic ulcers and other gastrointestinal disorders, and as a muscarinic receptor antagonist for diseases affecting cognition [including Alzheimer's disease]. Purity 99.91%
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Perfluorooctanoic acid (PFOA) (PFOA) is a persistent and widespread industry-made chemical. Purity 100%
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