Alkyl Halides
Medchemexpress LLC X-376 (Ensartinib) | 1365267-27-1 | 98.1% | 547.41 | 100 MG
X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM). It is a less potent inhibitor of MET (IC50=0.69 nM) and displays potent anti-tumor activity.
- Potent and highly specific ALK tyrosine kinase inhibitor
- Less potent inhibitor of MET
- Displays potent anti-tumor activity
Medchemexpress LLC Glun1 (356-385) | 99.95% | 3415.90 | 25 MG
GluN1 (356-385) is an antigenic peptide against N-methyl-D-aspartate receptor (NMDAR) encephalitis. It reduces the density of surface NMDAR clusters in hippocampal neurons and can be used to study the pathogenesis of anti-NMDAR encephalitis.
- Antigenic peptide against N-methyl-D-aspartate receptor encephalitis
- Reduces density of surface NMDAR clusters
- Suitable for studying anti-NMDAR encephalitis pathogenesis
- Inhibitor of ionotropic glutamate receptors
- Active immunization agent
Medchemexpress LLC Perfluoropentanoic acid (PFPeA) | 2706-90-3 | 98.0% | 264.05 | 100 G
Perfluoropentanoic acid (PFPeA) | 2706-90-3 | 98.0% | 264.05 | 100 G
Medchemexpress LLC GluN1(356-385) | 99.95% | 3415.90 | 10 MG
GluN1 (356-385) is an antigenic peptide against N-methyl-D-aspartate receptor (NMDAR) encephalitis. It reduces the density of surface NMDAR clusters in hippocampal neurons and can be used to study the pathogenesis of anti-NMDAR encephalitis.
- Antigenic peptide against NMDAR encephalitis
- Reduces density of surface NMDAR clusters in hippocampal neurons
- Used to study pathogenesis of anti-NMDAR encephalitis
- Related to peptide and derivatives, and peptide epitopes
- Applicable to neurological, eye or ear disease
- Associated with membrane transporter/ion channel, neuronal signaling, and iGluR pathways
Cayman Chemical 2H 2H 3H 3H-Perfluorodecanoic
A polyfluoroalkyl substance; has been found as a contaminant in freshwater reserves and marine seafood
Medchemexpress LLC Perfluorohexanoic acid (Undecafluorocaproic acid) | 307-24-4 | 99.90% | 314.05 | 500 MG
Perfluorohexanoic acid, also known as Undecafluorocaproic acid, is a biological molecule for research use only.
- High purity: 99.90%
- Molecular weight: 314.05
- Appearance: solid below 12°C, liquid above 14°C
- Color: colorless to off-white
- Formula: C6HF11O2
- Recommended storage: room temperature for 3 years; in solvent, -80°C for 2 years or -20°C for 1 year.
Medchemexpress LLC BAY-678 | 675103-36-3 | 99.6% | 400.35 | 100 MG
BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. It is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
- Orally bioavailable.
- Highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE).
- IC50 of 20 nM for HNE.
- Nominated as a chemical probe via the Structural Genomics Consortium (SGC).
- Ki value for MNE is 700 nM.
- 4th generation inhibitor of HNE.
- More than 2,000-fold selectivity in a panel of 21 serine proteases.
- Reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating anti-inflammatory and anti-remodeling mode of action.
- Shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.
Medchemexpress LLC 2-Pyridinecarbonitrile, 5-[(4R)-5-acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]- | 675103-36-3 | 99.6% | 400.35 | 25 MG
2-Pyridinecarbonitrile, 5-[(4R)-5-acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]- | 675103-36-3 | 99.6% | 400.35 | 25 MG
Medchemexpress LLC LMP2A (426-434) | 152274-91-4 | 96.1% | 906.16 | 10 MG
LMP2A (426-434) | 152274-91-4 | 96.1% | 906.16 | 10 MG
Cayman Chemical HeptafluorobutyrIc AcId 50g
A perfluoroalkyl substance; chronic topical administration on the EAr increases liver and kidney weight in mice at 25 µl of a 3.75-15% v/v on the EAr; induces multifocal hepatocyte necrosis and centrilobular hepatocyte hypertrophy at 7.5% v/v; increases serum cholesterol and ALP levels at 15% v/v; decreases serum urea nitrogen levels; has been found in marine life and as a contaminant in surface water
Medchemexpress LLC X-376 | 1365267-27-1 | 98.10% | 547.41 | 25 MG
X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) with an IC50 of 0.61 nM. It is also a less potent inhibitor of MET (IC50=0.69 nM) and exhibits potent anti-tumor activity.
- Effective in inhibiting the growth of various cancer cell lines, including H3122 lung cancer cells (IC50: 77 nM), H2228 lung cancer cells (IC50: 57 nM), and SUDHL-1 lymphoma cells (IC50: 32 nM).
- Also inhibits SY5Y neuroblastoma cells, MKN-45 gastric carcinoma cells, HepG2 cells, and PC-9 lung cancer cell lines.
- Demonstrates substantial bioavailability and moderate half-lives in vivo.
- Significantly delays tumor growth in H3122 xenografts at a dose of 50 mg/kg bid, appearing well-tolerated without affecting mouse weight or causing compound-related toxicity.
TARGETMOL CHEMICALS INC X-376 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration X-396 binds to and inhibits ALK kinase ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. purity: 98%