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Organic compounds in which a hydrogen atom or more has been replaced by a halogen atom in an alkane molecule (saturated hydrocarbon chain). Halogen atoms include bromine, chlorine, fluorine, and iodine. Compounds may be in closed ring configurations.
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MK-4101 is a small-molecule Smoothened (SMO) antagonist that inhibits the Hedgehog signaling pathway and is intended for preclinical research applications. It has molecular formula C24H24F5N5O and a molecular weight of 493.47 g/mol, and is used in studies of pathway modulation, apoptosis, and oncology-related biology.
Potent Smoothened (SMO) antagonist with cellular activity
Inhibits Hedgehog signaling for pathway modulation studies
High purity suitable for preclinical assays
Available in small-scale weights for laboratory research
Soluble in DMSO for preparation of stock solutions
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Bis(2-bromoethyl) ether is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Alkyl chain-based PROTAC linker
Used in the synthesis of PROTACs
PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More