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Organic compounds in which a hydrogen atom or more has been replaced by a halogen atom in an alkane molecule (saturated hydrocarbon chain). Halogen atoms include bromine, chlorine, fluorine, and iodine. Compounds may be in closed ring configurations.
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UC-112 is a survivin and XIAP modulator that demonstrates anticancer activity. It works by selectively downregulating and degrading survivin through the ubiquitin-mediated proteasomal degradation pathway. It also reduces XIAP levels in in vivo tumor models, activates caspase-3/7 and caspase-9, and induces apoptosis in cancer cells. This product is for research use only and not for patient use.
Selectively downregulates and degrades survivin
Reduces XIAP levels in in vivo tumor models
Activates caspase-3/7 and caspase-9, inducing cancer cell apoptosis
Inhibits proliferation of A375, M14, PC-3, and DU145 cancer cells
Inhibits human melanoma tumor growth in nude mice
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Recombinant mouse CCL4 (C-C motif chemokine ligand 4) is a proinflammatory chemokine expressed in E. coli and supplied lyophilized for research use. It promotes leukocyte chemotaxis, acts as a monokine that can form homodimers, and is provided with high purity suitable for in vitro studies of inflammation and immune cell migration.
High purity (>95%) as determined by reducing SDS-PAGE.
Recombinant expression in E. coli without affinity tag.
Supplied lyophilized from buffered formulation for stability.
Predicted molecular mass ~7.8 kDa (observed ~5-10 kDa by SDS-PAGE).
Intended for in vitro research applications studying chemotaxis and inflammation.
Stable when aliquoted and stored at -20°C or -80°C for extended storage.
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Dichloromethane is a chlorinated organic solvent that is susceptible to degradation with time. This can be suppressed by adding amylene as a stabilizer.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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hsa-miR-122-5p mimics are small chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity
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