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Organic compounds in which a hydrogen atom or more has been replaced by a halogen atom in an alkane molecule (saturated hydrocarbon chain). Halogen atoms include bromine, chlorine, fluorine, and iodine. Compounds may be in closed ring configurations.
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Bromo-PEG8-bromide is a bifunctional polyethylene glycol (PEG) linker bearing terminal bromide groups on both ends. It is a hydrophilic spacer useful for nucleophilic substitution reactions and bioconjugation in drug-delivery research and linker synthesis for antibody-drug conjugates and PROTACs. Molecular formula C18H36Br2O8, molecular weight 540.28 g/mol, CAS 2376383-09-2.
Bifunctional PEG linker with terminal bromide groups for facile nucleophilic substitution.
Enhances solubility and flexibility of conjugates in aqueous media.
Suitable for bioconjugation and linker synthesis in drug-delivery research.
Useful for constructing linkers in ADC and PROTAC workflows.
Typically supplied as a liquid for straightforward handling.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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MK-4101 is a small-molecule Smoothened (SMO) antagonist and hedgehog pathway inhibitor used for research applications, including in vitro pathway studies and preclinical cancer research. It shows antitumor activity by inhibiting tumor cell proliferation and inducing apoptosis.
Small-molecule SMO antagonist suitable for in vitro and preclinical studies.
High reported purity of 99.16%.
Molecular weight 493.47 g/mol and formula C24H24F5N5O.
Soluble in DMSO at ≥50 mg/mL; in vivo formulation protocols available.
Recommended storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years).
Reported cellular potency in the low micromolar range (IC50 values).
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2-Methylpropane-2-sulfinamide is an amide compound utilized as an intermediate in pharmaceutical synthesis. It is employed in the synthesis of 4-sulfonimidoylpiperidine and reacts with benzyl Grignard reagent to produce 4-benzyl-4-aminopiperidine, which is a significant pharmaceutical building block. Additionally, it can be used to insert a methylene group into derivatized sulfonimides for the creation of spiro-tosylaziridines.
Used as an intermediate in pharmaceutical synthesis.
Employed in the synthesis of 4-sulfonimidoylpiperidine.
Reacts with benzyl Grignard reagent to produce 4-benzyl-4-aminopiperidine.
Can be used to insert a methylene group into derivatized sulfonimides for the creation of spiro-tosylaziridines.
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