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Organic compounds that are derived from or have a benzene group in their molecular structure. Benzene is an aromatic organic molecule composed of 6 carbon atoms and 6 hydrogen atoms that form a ring. Includes derivatives and substituted molecules.
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Guanfacine hydrochloride is an orally active and blood-brain barrier permeable noradrenergic α2A agonist that exhibits high selectivity for the α2A receptor subtype. It has demonstrated effects in producing hypotension and sedation. This compound can be utilized for research into various prefrontal cortex (PFC) cognitive disorders, such as Tourette's syndrome and attention deficit hyperactivity disorder (ADHD).
Orally active
Blood-brain barrier permeable
Noradrenergic α2A agonist
High selectivity for the α2A receptor subtype
Produces hypotension and sedation
Used for research into prefrontal cortex (PFC) cognitive disorders
Potentially useful for Tourette's syndrome
Potentially useful for attention deficit hyperactivity disorder (ADHD)
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An agonist of ERα and active metabolite of daidzein; induces ERα-mediated gene transcription selectively over ERβ-mediated transcription in HEC-1 cells expressing the human receptors in a reporter assay (EC50s = 66 and 330 nM, respectively)
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