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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
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Bay 65-1942 hydrochloride is an ATP-competitive, selective inhibitor of IKKβ used in research to probe NF-κB signaling and inflammatory pathways. It is supplied as the hydrochloride salt to improve solubility and handling, and is intended for use in biochemical and cell-based assays.
Selective inhibition of IKKβ for pathway interrogation.
ATP-competitive mode of action suitable for biochemical assays.
High reported purity for reproducible results.
Hydrochloride salt with improved solubility in DMSO and aqueous buffers.
Suitable for biochemical and cell-based assay applications.
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Butyne-DOTA-tris(t-butyl ester) is a bifunctional DOTA-derived chelator supplied for research applications. It features a terminal alkyne for bioorthogonal conjugation and tert-butyl protected carboxylate arms that can be deprotected to expose the DOTA chelator for metal coordination, supporting peptide conjugation and radionuclide labeling workflows.
Terminal alkyne handle for click chemistry conjugation.
Three tert-butyl protected carboxylate arms for controlled deprotection.
Macrocyclic DOTA core for stable metal chelation.
High reported purity suitable for analytical and preparative use.
Available in small milligram quantities for research-scale experiments.
Provided with supporting documentation such as SDS, COA, NMR, and HPLC data.
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A monounsaturated fatty acid and isomer of oleic acid; major component of plant lipids; rats fed a diet containing it have a reduction in arachidonic acid levels and an increase in linoleic acid levels in the heart, liver, and blood; has been used in a composite membrane to study plant uptake; has been used in the synthesis of new biosurfactants (sophorolipids)
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Bpin-Cyclohexene-COOEt is a PROTAC linker from the PEG class, primarily used in the synthesis of PROTAC molecules. This chemical appears as a colorless to light yellow liquid, suitable for laboratory research and the manufacture of substances. It is important to note that this product is intended for research purposes only and has not been validated for medical applications.
PROTAC linker for synthesizing PROTAC molecules
Clear to light yellow liquid appearance
Purity greater than or equal to 97.0%
Molecular weight of 280.17
Store pure form at -20°C for up to 3 years
Unstable in solutions; use freshly prepared solutions
Stable under recommended storage conditions
Intended for research use only
Not validated for medical applications
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I-BET-762 (CAS 1260907-17-2) is a small-molecule inhibitor targeting the BET (bromodomain and extra-terminal) family of proteins It acts by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains thereby displacing acetylated histones with an IC50 ranging from 32 5 to 42 5 nM and a dissociation constant (Kd) between 50 5 and 61 3 nM I-BET-762 displays high selectivity exhibiting no interaction with non-BET bromodomain-containing proteins In cellular studies it downregulates LPS-induced gene expression resulting in reduced production of pro-inflammatory cytokines and chemokines In vivo models demonstrate its potential to attenuate features of established inflammatory disease supporting its utility in epigenetic and inflammation-related research
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