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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
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Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50 13/26 nM in cell-free assays). purity: 99%
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NO2A-Butyneis a bifunctional chelator (Bifunctional Chelator BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting NO2A-Butyne can be used for conjugation of peptides and radionuclides
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9-cis-β-Carotene is a precursor of retinal, cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. It inhibits photoreceptor degeneration and restores retinal function in vivo, with potential for the study of congenital stationary night blindness and fundus albipunctatus.
Inhibits photoreceptor degeneration.
Restores retinal function in vivo.
Potential for studying congenital stationary night blindness.
Potential for studying fundus albipunctatus.
Prevents S- and M-cone degeneration in eye cups.
Rescues retinal function and preserves cone structure in a mouse model of retinoid cycle defect.
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A monounsaturated fatty acid and isomer of oleic acid; major component of plant lipids; rats fed a diet containing it have a reduction in arachidonic acid levels and an increase in linoleic acid levels in the heart, liver, and blood; has been used in a composite membrane to study plant uptake; has been used in the synthesis of new biosurfactants (sophorolipids)
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VE-821 (CAS 1232410-49-9) is a selective ATP-competitive inhibitor of ATR (ataxia telangiectasia and Rad3-related) kinase a critical regulator involved in DNA damage response signaling VE-821 exhibits potent ATR inhibition with a Ki value of 13 nM and minimal off-target activity toward other PI3K-related kinases such as ATM DNA-PK mTOR and PI3K In cellular models VE-821 effectively reduces phosphorylation of ATR substrates including Chk1 at Ser345 thereby sensitizing HL-60 leukemia and pancreatic cancer cell lines (e g PSN-1 MiaPaCa-2) to chemotherapy (gemcitabine) and radiation-induced cytotoxicity VE-821 is utilized as a research tool in the study of DNA damage responses and cancer vulnerabilities
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