Hydrocarbons
Apexbio Technology LLC I-BET-762 1260907-17-2 5mg
I-BET-762 (CAS 1260907-17-2) is a small-molecule inhibitor targeting the BET (bromodomain and extra-terminal) family of proteins It acts by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains thereby displacing acetylated histones with an IC50 ranging from 32 5 to 42 5 nM and a dissociation constant (Kd) between 50 5 and 61 3 nM I-BET-762 displays high selectivity exhibiting no interaction with non-BET bromodomain-containing proteins In cellular studies it downregulates LPS-induced gene expression resulting in reduced production of pro-inflammatory cytokines and chemokines In vivo models demonstrate its potential to attenuate features of established inflammatory disease supporting its utility in epigenetic and inflammation-related research
Selleck Chemical LLC VE-821
VE-821(ATR inhibitor IV) is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays shows inhibition of H2AX phosphorylation minimal activity against PIKKs ATM DNA-PK mTOR and PI3K
![eMolecules 12354-85-7 | PENTAMETHYLCYCLOPENTADIENYLRHODIUM(III) CHLORIDE DIMER | AstaTech618.070 | C20H30Cl4Rh2 | 95.000 | [Cl-].[Cl-].[Cl-].[Cl-].CC12C3(C)C4(C)C5(C)C1(C)[Rh++]2345.CC12C3(C)C4(C)C5(C)C1(C)[Rh++]2345 | 0.25g | 449765095](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502465778.JPG-250.jpg)
eMolecules 12354-85-7 | PENTAMETHYLCYCLOPENTADIENYLRHODIUM(III) CHLORIDE DIMER | AstaTech618.070 | C20H30Cl4Rh2 | 95.000 | [Cl-].[Cl-].[Cl-].[Cl-].CC12C3(C)C4(C)C5(C)C1(C)[Rh++]2345.CC12C3(C)C4(C)C5(C)C1(C)[Rh++]2345 | 0.25g | 449765095
PENTAMETHYLCYCLOPENTADIENYLRHODIUM(III) CHLORIDE DIMER | AstaTech | 12354-85-7618.070 | C20H30Cl4Rh2 | 95.000 | [Cl-].[Cl-].[Cl-].[Cl-].CC12C3(C)C4(C)C5(C)C1(C)[Rh++]2345.CC12C3(C)C4(C)C5(C)C1(C)[Rh++]2345 | 0.25g | 449765095
eMolecules 6760-99-2 | 8-Aza-bicyclo[3.2.1]octane hydrochloride | J & W PharmLab LLC | MFCD19982561 | 147.650 | C7H14ClN | 96.000 | Cl.C1CC2CCCC1N2 | 100mg | 525314441
8-Aza-bicyclo[3.2.1]octane hydrochloride | J & W PharmLab LLC | 6760-99-2 | MFCD19982561 | 147.650 | C7H14ClN | 96.000 | Cl.C1CC2CCCC1N2 | 100mg | 525314441
![eMolecules 2007921-20-0 | 3-aminobicyclo[1.1.1]pentan-1-ol HCl | Ambeed | MFCD28501812 | 135.590 | C5H10ClNO | 98.000 | Cl.NC12CC(O)(C1)C2 | 100mg | 786459295](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000126499.jpg-250.jpg)
eMolecules 2007921-20-0 | 3-aminobicyclo[1.1.1]pentan-1-ol HCl | Ambeed | MFCD28501812 | 135.590 | C5H10ClNO | 98.000 | Cl.NC12CC(O)(C1)C2 | 100mg | 786459295
3-aminobicyclo[1.1.1]pentan-1-ol HCl | Ambeed | 2007921-20-0 | MFCD28501812 | 135.590 | C5H10ClNO | 98.000 | Cl.NC12CC(O)(C1)C2 | 100mg | 786459295
![Aobchem Bicyclo[4 2 0]octa-1 3 5-triene-3-carboxaldehyde | ≥97% | CAS 112892-88-3 | C9H8O | 500mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000903541.png-250.jpg)
Aobchem Bicyclo[4 2 0]octa-1 3 5-triene-3-carboxaldehyde | ≥97% | CAS 112892-88-3 | C9H8O | 500mg
Bicyclo[4 2 0]octa-1 3 5-triene-3-carboxaldehyde | ≥97% | CAS 112892-88-3 | C9H8O | 500mg
![eMolecules 1414958-33-0 | 6-Oxa-3-aza-bicyclo[3.1.1]heptane hydrochloride | J & W PharmLab LLC | MFCD22689277 | 135.590 | C5H10ClNO | 96.000 | Cl.C1C2CNCC1O2 | 100mg | 517669102](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000474077.jpg-250.jpg)
eMolecules 1414958-33-0 | 6-Oxa-3-aza-bicyclo[3.1.1]heptane hydrochloride | J & W PharmLab LLC | MFCD22689277 | 135.590 | C5H10ClNO | 96.000 | Cl.C1C2CNCC1O2 | 100mg | 517669102
6-Oxa-3-aza-bicyclo[3.1.1]heptane hydrochloride | J & W PharmLab LLC | 1414958-33-0 | MFCD22689277 | 135.590 | C5H10ClNO | 96.000 | Cl.C1C2CNCC1O2 | 100mg | 517669102
![eMolecules 1638767-25-5 | tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl)carbamate | Combi-Blocks | MFCD27987307 | 198.266 | C10H18N2O2 | 98.000 | CC(C)(C)OC(=O)NC12CC(N)(C1)C2 | 1g | 517113968](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000165288.jpg-250.jpg)
eMolecules 1638767-25-5 | tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl)carbamate | Combi-Blocks | MFCD27987307 | 198.266 | C10H18N2O2 | 98.000 | CC(C)(C)OC(=O)NC12CC(N)(C1)C2 | 1g | 517113968
tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl)carbamate | Combi-Blocks | 1638767-25-5 | MFCD27987307 | 198.266 | C10H18N2O2 | 98.000 | CC(C)(C)OC(=O)NC12CC(N)(C1)C2 | 1g | 517113968
![eMolecules 493-02-7 | Trans-decahydronaphthalene | Combi-Blocks138.254 | C10H18 | 98.000 | C1CC[C@H]2CCCC[C@@H]2C1 | 5g | 342862295](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00128114-342862295.PNG-250.jpg)
eMolecules 493-02-7 | Trans-decahydronaphthalene | Combi-Blocks138.254 | C10H18 | 98.000 | C1CC[C@H]2CCCC[C@@H]2C1 | 5g | 342862295
Trans-decahydronaphthalene | Combi-Blocks | 493-02-7138.254 | C10H18 | 98.000 | C1CC[C@H]2CCCC[C@@H]2C1 | 5g | 342862295
Medchemexpress LLC NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride | 98.5% | 509.94 | 25 MG
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (compound I) hydrochloride is a topoisomerase I inhibitor that demonstrates good ADC (Antibody-Drug Conjugate) activity both in vivo and in vitro, and can be delivered to cells through conjugated antibody targeting.
- Functions as a topoisomerase I inhibitor.
- Designed for targeted delivery to cells via conjugated antibodies.
- Shows effective ADC activity both in vivo and in vitro.