Ciproxifan maleate is a potent, selective, orally bioavailable, and competitive antagonist of the histamine H3-receptor, with an IC50 of 9.2 nM. It shows low apparent affinity at other receptor subtypes and can be used for research of aging disorders and Alzheimer's disease.
- Potent and selective antagonist of histamine H3-receptor
- Orally bioavailable
- Useful for research on aging disorders and Alzheimer's disease
- Inhibits [3H]HA release from rat cerebral cortex synaptosomes
- Improves accuracy in five-choice tasks in rats
- Induces neocortical electroencephalogram activation in cats
- Exhibits oral bioavailability in mice