Organic acids and derivatives
Apexbio Technology LLC Baricitinib phosphate(Synonyms: Baricitinib phosphate, Olumiant phosphate, LY3009104 phosphate, INCB028050 phosphate), 10mg, CAS: 1187595-84-1.
Baricitinib phosphate (CAS 1187595-84-1) known as INCB028050 is an orally bioavailable small molecule inhibitor targeting Janus kinases JAK1 and JAK2 It selectively inhibits JAK1 and JAK2 with IC50 values of approximately 5 9 nM and 5 7 nM respectively exhibiting roughly 10-fold lower potency towards JAK3 and Tyk2 and lacking inhibition against c-Met and Chk2 By suppressing JAK1/2-mediated signaling baricitinib phosphate reduces signal transduction induced by proinflammatory cytokines such as IL-6 and IL-23 in vitro Preclinical studies in rodent arthritis models indicate notable therapeutic activity with minimal evidence of adverse hematological or immunosuppressive effects This compound is used widely in biomedical research for investigating inflammatory pathways in autoimmune disease models
