Organoheterocyclic compounds
5-Bromo-2-chloropyridine, 98%
CAS: 53939-30-3 Molecular Formula: C5H3BrClN Molecular Weight (g/mol): 192.44 MDL Number: MFCD01318951 InChI Key: PEAOEIWYQVXZMB-UHFFFAOYSA-N Synonym: 2-chloro-5-bromopyridine,5-bromo-2-chloro-pyridine,pyridine, 5-bromo-2-chloro,2-chloro-5-bromo-pyridine,2-chlorine-5-bromine pyridine,pubchem1168,acmc-1afhf,3-bromo-6-chloropyridine,2-chloro-5-bromo pyridine,3-bromo-6-chloro-pyridine PubChem CID: 2734414 IUPAC Name: 5-bromo-2-chloropyridine SMILES: C1=CC(=NC=C1Br)Cl
3-Bromo-5-fluoropyridine, 97%
CAS: 407-20-5 Molecular Formula: C5H3BrFN Molecular Weight (g/mol): 175.99 MDL Number: MFCD04112555 InChI Key: HNNNBQRRIHKFLI-UHFFFAOYSA-N Synonym: 5-bromo-3-fluoropyridine,3-bromo-5-fluoro-pyridine,3-brom-5-fluorpyridin,3-bromo-5-fluoro pyridine,pyridine, 3-bromo-5-fluoro,3-bromo-5-fluorpyridine,5-bromo-3-fluoride pyridine,3-bromine-5-fluoride pyridine,pubchem3964,3-bromo-5-fluoropyridin PubChem CID: 820206 IUPAC Name: 3-bromo-5-fluoropyridine SMILES: FC1=CN=CC(Br)=C1
5-Bromo-2-chloropyridine, 98%, Thermo Scientific™
CAS: 53939-30-3 Molecular Formula: C5H3BrClN Molecular Weight (g/mol): 192.44 MDL Number: MFCD01318951 InChI Key: PEAOEIWYQVXZMB-UHFFFAOYSA-N Synonym: 2-chloro-5-bromopyridine,5-bromo-2-chloro-pyridine,pyridine, 5-bromo-2-chloro,2-chloro-5-bromo-pyridine,2-chlorine-5-bromine pyridine,pubchem1168,acmc-1afhf,3-bromo-6-chloropyridine,2-chloro-5-bromo pyridine,3-bromo-6-chloro-pyridine PubChem CID: 2734414 IUPAC Name: 5-bromo-2-chloropyridine SMILES: C1=CC(=NC=C1Br)Cl
3-Bromo-5-fluoropyridine, 97%
CAS: 407-20-5 Molecular Formula: C5H3BrFN Molecular Weight (g/mol): 175.99 MDL Number: MFCD04112555 InChI Key: HNNNBQRRIHKFLI-UHFFFAOYSA-N Synonym: 5-bromo-3-fluoropyridine,3-bromo-5-fluoro-pyridine,3-brom-5-fluorpyridin,3-bromo-5-fluoro pyridine,pyridine, 3-bromo-5-fluoro,3-bromo-5-fluorpyridine,5-bromo-3-fluoride pyridine,3-bromine-5-fluoride pyridine,pubchem3964,3-bromo-5-fluoropyridin PubChem CID: 820206 IUPAC Name: 3-bromo-5-fluoropyridine SMILES: FC1=CN=CC(Br)=C1
5-Bromo-2-chloropyridine 98.0+%, TCI America™
CAS: 53939-30-3 Molecular Formula: C5H3BrClN Molecular Weight (g/mol): 192.44 MDL Number: MFCD01318951 InChI Key: PEAOEIWYQVXZMB-UHFFFAOYSA-N Synonym: 2-chloro-5-bromopyridine,5-bromo-2-chloro-pyridine,pyridine, 5-bromo-2-chloro,2-chloro-5-bromo-pyridine,2-chlorine-5-bromine pyridine,pubchem1168,acmc-1afhf,3-bromo-6-chloropyridine,2-chloro-5-bromo pyridine,3-bromo-6-chloro-pyridine PubChem CID: 2734414 IUPAC Name: 5-bromo-2-chloropyridine SMILES: C1=CC(=NC=C1Br)Cl
3-Bromo-5-fluoropyridine 98.0+%, TCI America™
CAS: 407-20-5 Molecular Formula: C5H3BrFN Molecular Weight (g/mol): 175.99 MDL Number: MFCD04112555 InChI Key: HNNNBQRRIHKFLI-UHFFFAOYSA-N Synonym: 5-bromo-3-fluoropyridine,3-bromo-5-fluoro-pyridine,3-brom-5-fluorpyridin,3-bromo-5-fluoro pyridine,pyridine, 3-bromo-5-fluoro,3-bromo-5-fluorpyridine,5-bromo-3-fluoride pyridine,3-bromine-5-fluoride pyridine,pubchem3964,3-bromo-5-fluoropyridin PubChem CID: 820206 IUPAC Name: 3-bromo-5-fluoropyridine SMILES: FC1=CN=CC(Br)=C1
Sigma Organic Chemistry Poly(thiophene-2,5-diyl), bromine terminated | 1G | 25233-34-5 | MFCD02688620
Poly(thiophene-2,5-diyl), bromine terminated, 1G
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Storage: room temp
TARGETMOL CHEMICALS INC CPI-0610 CARBOXYLIC ACID 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. CPI-0610 carboxylic acid is an effective and selective small molecule inhibitor of bromine domain and outer end (BET) protein as a ligand of PROTAC target protein. CPI-0610 carboxylic acid may have anticancer and anticancer activities. purity: 98%
Apexbio Technology LLC 5-BR-UTP 100UL 100 MM
5-Br-UTP is a chemically modified ribonucleoside triphosphate that incorporates a bromine substituent at the 5 position of uracil Upon enzymatic incorporation into RNA sequences this compound confers enhanced structural stability and tolerance to enzymatic degradation by nucleases Such modified ribonucleotides are frequently employed in SELEX (Systematic Evolution of Ligands by EXponential enrichment) methodologies to generate aptamers exhibiting improved resistance to nucleolytic cleavage and greater thermal robustness Consequently 5-Br-UTP holds relevance for RNA-based therapeutic research and aptamer engineering applications
Apexbio Technology LLC 5-Br-CTP 50ul (100 mM)
5-Br-CTP is a modified ribonucleoside triphosphate It is designed for use in the generation of RNA libraries via Systematic Evolution of Ligands by EXponential enrichment (SELEX) facilitating the selection of aptamers with enhanced stability Nucleic acids synthesized with 5-Br-CTP display improved resistance to nuclease degradation and increased thermal stability due to bromine substitution at the C-5 position of the cytosine base Based on these properties 5-Br-CTP holds research potential in aptamer selection and nucleic acid-based applications requiring enhanced structural integrity under stringent conditions
Apexbio Technology LLC 5-Br-CTP 100ul (100 mM)
5-Br-CTP is a modified ribonucleoside triphosphate It is designed for use in the generation of RNA libraries via Systematic Evolution of Ligands by EXponential enrichment (SELEX) facilitating the selection of aptamers with enhanced stability Nucleic acids synthesized with 5-Br-CTP display improved resistance to nuclease degradation and increased thermal stability due to bromine substitution at the C-5 position of the cytosine base Based on these properties 5-Br-CTP holds research potential in aptamer selection and nucleic acid-based applications requiring enhanced structural integrity under stringent conditions
Apexbio Technology LLC 5-Br-CTP 10ul (100 mM)
5-Br-CTP is a modified ribonucleoside triphosphate It is designed for use in the generation of RNA libraries via Systematic Evolution of Ligands by EXponential enrichment (SELEX) facilitating the selection of aptamers with enhanced stability Nucleic acids synthesized with 5-Br-CTP display improved resistance to nuclease degradation and increased thermal stability due to bromine substitution at the C-5 position of the cytosine base Based on these properties 5-Br-CTP holds research potential in aptamer selection and nucleic acid-based applications requiring enhanced structural integrity under stringent conditions
Apexbio Technology LLC SGC 0946 1561178-17-3 5mg
SGC 0946 (CAS 1561178-17-3) is a small molecule inhibitor targeting DOT1L a histone methyltransferase responsible for methylation of lysine 79 on histone H3 (H3K79) By selectively inhibiting DOT1L catalytic activity SGC 0946 disrupts H3K79 methylation showing potent inhibitory potency (IC50 0 3 nM) In cellular assays SGC 0946 reduces H3K79 methylation in MCF10A and A431 cell lines with IC50 values of 8 8 nM and 2 65 nM respectively Structurally related to EPZ004777 but as a brominated analog SGC 0946 has improved cellular permeability and prolonged target residence time facilitating research in epigenetic regulation
Apexbio Technology LLC TH-302 918633-87-1 200mg
TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity
Apexbio Technology LLC TH-302 918633-87-1 5mg
TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity
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