Organoheterocyclic compounds
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Medchemexpress LLC Ossirene | 106566-58-9 | 98.0% | 312.05 | 5 MG
Ossirene is an immunomodulatory tellurium compound and a potent IL-1β inhibitor. It abolishes phosphorylation of STAT3 by inhibiting IL-10 and potently inhibits Caspase-1. This compound is used for autoimmune diseases and certain malignancies.
- Potent IL-1β inhibitor
- Inhibits phosphorylation of STAT3 by suppressing IL-10
- Potently inhibits Caspase-1
- Used for autoimmune diseases and certain malignancies
- Sensitizes glioblastoma multiforme (GBM) tumors to paclitaxel
- Decreases proliferation of B16 melanoma, stomach adenocarcinoma, and human GBM cells
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Medchemexpress LLC Ammonium trichloro(dioxoethylene-o,o')tellurate | 106566-58-9 | 98.0% | 312.05 | C2H8Cl3NO2Te | 10 MG
Ossirene (AS101) is an immunomodulatory tellurium compound used in research as a potent IL-1β inhibitor. It abolishes phosphorylation of STAT3 by inhibiting IL-10 and potently inhibits caspase-1, making it useful for studies of autoimmune disease and certain malignancies.
- Potent IL-1β inhibitor.
- Inhibits caspase-1.
- Abolishes STAT3 phosphorylation via IL-10 inhibition.
- Purity ≥98.0%.
- Solid, white to off-white appearance.
- Molecular weight 312.05 g/mol.
- Supplied as 10 mg.
- Store at -20°C under nitrogen; in solvent, -80°C (up to 6 months).