Organonitrogen Compounds
Apexbio Technology LLC MRTX-1133(Synonyms: MRTX1133, MRTX 1133, Mirati-1133, KRAS G12D inhibitor MRTX1133), 10mg, CAS: 2621928-55-8.
MRTX-1133 (CAS 2621928-55-8) is a non-covalent alkyne-based inhibitor specifically targeting the KRAS G12D mutant protein It binds KRAS G12D with sub-picomolar affinity occupying the Switch II pocket and forming multiple intermolecular interactions Through these interactions MRTX-1133 disrupts SOS1-mediated guanine nucleotide exchange and prevents the assembly of KRAS-GTP/RAF1 signaling complexes thereby inhibiting downstream KRAS-driven signaling pathways MRTX-1133 is applied in cancer biology research to investigate tumor signaling and therapeutic strategies involving KRAS G12D mutations
Medchemexpress LLC Guanidine hydrochloride | 50-01-1 | 98.0% | 25 G
Guanidine hydrochloride is a strong chaotrope and denaturant of proteins, widely used in biochemical research. It causes co-operative unfolding of the molten globule state at high concentrations and can refold acid-unfolded proteins at low concentrations.
- Induces co-operative unfolding of the molten globule state at concentrations greater than 1 M.
- Refolds acid-unfolded apomyoglobin and cytochrome c at low concentrations.
- Stabilizes the molten globule state.
- Does not affect disulfide bonds.
- Can cause efficient loss of the [PSI+] element from yeast cells at millimolar concentrations.
- Reduces Hsp104-mediated basal and acquired thermotolerance.
- Reduces Hsp104's ability to restore activity of thermally denatured luciferase.
- In vivo, significantly reduces the death rate of infant mice infected with coxsackievirus A16.
eMolecules 2229025-70-9 | Medchem Express | WM-3835 | 5mg | 599150697 | HY-134901 | 400.42 | C20H17FN2O4S
Ambeed | alpha-Pyrone | 100mg | 570569947 | A612059 | 504-31-4 | MFCD00006639 | 96.085 | C5H4O2
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Medchemexpress LLC Ask1-in-2 | 2541792-70-3 | 99.6% | 364.38 g·mol⁻¹ | C19H17FN6O | 5 MG
ASK1-IN-2 is a small-molecule, orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 32.8 nM. It is supplied as a white to off-white solid and is available in multiple package sizes and as DMSO solutions for research use; preclinical studies report activity in dextran sulfate sodium (DSS)-induced ulcerative colitis models.
- Potent ASK1 inhibition (IC50 32.8 nM).
- Orally active compound demonstrated in preclinical models.
- Shown to improve DSS-induced ulcerative colitis in mice.
- Blocks ASK1-p38/JNK signaling and reduces inflammatory cytokines.
- High purity (99.6%) and solid, white to off-white physical form.
- Available as solid, solid + solvent, and solution formats for flexible use.
- Powder storage: -20°C for long-term stability; solvent storage guidelines provided.