Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine, a selective serotonin (5-HT) reuptake inhibitor, is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. This compound inhibits 5-HT uptake and CaV3.3 T current with an IC50 of 5 μM. Additionally, Norfluoxetine hydrochloride demonstrates anticonvulsant activity.
- Active N-demethylated metabolite of fluoxetine.
- Inhibits 5-HT uptake.
- Inhibits CaV3.3 T current (IC50 = 5 μM).
- Exhibits anticonvulsant activity.