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3-Bromopyruvic acid (CAS 1113-59-3) abbreviated as 3-BP is a small molecule inhibitor that targets hexokinase II (HK2) an enzyme notably upregulated in cancerous cells By inhibiting HK2 activity (Ki 2 4 mM) 3-BP interferes with glycolytic energy metabolism leading to reduced tumor cell proliferation in hepatocellular carcinoma BEL-7402 cells In mouse xenograft models of hepatocellular carcinoma administration of 3-BP (50 mg/kg/day six days weekly for three weeks) results in decreased tumor growth and increased tumor necrosis This compound serves as a tool in oncology research particularly for studying glycolysis-dependent tumor metabolism
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Trans-R-138727 is the trans isomer of R-138727, the thiol-containing active metabolite of the antiplatelet agent prasugrel. It is supplied as a high-purity research chemical for biochemical and pharmacological studies, including platelet P2Y12 receptor inhibition assays and metabolite characterization.
High purity suitable for analytical and biological assays.
Useful as a reference standard and pharmacological tool.
Provided as a powder with low-temperature storage recommendations.
Molecular weight 349.42 g/mol and formula C18H20FNO3S.
Available in milligram-scale quantities for research use.
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Chemical. Formula C18H26O5. MW 322.4. Isolated from Paraspheaoshaeria sp. Unique fungal allene derivative. Similar to A 82775C and iso-A 82775C. Biological activity not tested yet.
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