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ML604086 is a selective small-molecule inhibitor of the chemokine receptor CCR8 developed for laboratory research. It inhibits CCL1 binding to CCR8, blocks CCL1-mediated chemotaxis, and increases intracellular Ca2+ in CCR8-expressing cells, with reported micromolar activity in vitro.
Selective CCR8 small-molecule inhibitor for research use.
Inhibits CCL1 binding to CCR8 and blocks chemotaxis.
Increases intracellular Ca2+ concentrations in CCR8-expressing cells.
Reported in vitro IC50 ~1.0-1.3 μM in CCR8 assays.
Chemical formula C27H32N4O4S; molecular weight 508.63 g·mol⁻¹.
Purity listed as 99.78% (supplier assay).
Available as powder and as 10 mM solution in DMSO, with multiple pack sizes including 25 mg.
Intended for research use only; not for human use.
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