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Azido-PEG4-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. It acts as a click chemistry reagent, featuring an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. It also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs employ two ligands linked by a linker-one for an E3 ubiquitin ligase and another for the target protein-to selectively degrade target proteins via the intracellular ubiquitin-proteasome system.
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DO2A-tert-butyl ester is a tert-butyl-protected DOTA-like bifunctional chelator used as a synthetic building block for preparing metal-chelator conjugates and radionuclide-labeled probes in biochemical and radiochemistry applications. The compound has molecular formula C20H40N4O4 and a molecular weight of 400.56 g·mol⁻¹; store protected from light at 4°C and follow solvent storage guidelines for long-term stability.
Suitable for chelator-biomolecule conjugation
Protected ester functionality for controlled deprotection
Applicable for radionuclide labeling workflows
Solid reagent with defined molecular composition
Stable under recommended storage conditions
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