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Sulfanilamide (Sulphanilamide) is a potent and orally active sulfonamide antibiotic and can be a major intermediate of sulfamethoxazole biodegradation. It is also a carbonic anhydrase inhibitor and shows inhibition on the virus of lymphogranuloma venereum.
Potent and orally active sulfonamide antibiotic
Major intermediate of sulfamethoxazole biodegradation
Carbonic anhydrase inhibitor
Shows inhibition on the virus of lymphogranuloma venereum
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Sulfathiazole is an orally active endocrine disruptor that targets the steroidogenic pathway. It enhances CYP19 activity in human adrenal cancer cells and upregulates the mRNA expression of CYP17, CYP19, and 3β-HSD. This compound increases 17-estradiol (E2) production and exhibits endocrine disrupting effects on aquatic organisms.
Orally active endocrine disruptor
Targets the steroidogenic pathway
Enhances CYP19 activity in human adrenal cancer cells
Upregulates mRNA expression of CYP17, CYP19, and 3β-HSD
Increases 17-estradiol (E2) production
Exhibits endocrine disrupting effects on aquatic organisms
Shows antibacterial properties
Effective in inhibiting copper corrosion in 0.1 M NaCl solution
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Sulfathiazole is an orally active endocrine disruptor that targets the steroidogenic pathway. It enhances the activity of CYP19 in human adrenal cancer cells (H295R) and has endocrine-disrupting effects on aquatic organisms.
Enhances CYP19 activity in human adrenal cancer cells (H295R).
Upregulates mRNA expression of CYP17, CYP19, and 3β-HSD.
Increases production of 17-estradiol (E2).
Exhibits endocrine-disrupting effects on aquatic organisms like the Japanese medaka fish.
For research use only.
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Sulfapyridine is a sulfonamide antibiotic agent and a major metabolite of Sulfasalazine. It inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. It exhibits antibacterial, anti-inflammatory, and anti-rheumatic activities.
Inhibits recombinant P. carinii dihydropteroate synthetase (DHPS)
Exhibits antibacterial properties
Possesses anti-inflammatory activity
Shows anti-rheumatic activity
Inhibits production of IL-8, CXCL1, and MCP-1 in synovial cells of rheumatoid arthritis (RA)
Significantly inhibits systemic allergic reactions induced by compound 48/80 in rats
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Sulfanilamide is a potent and orally active sulfonamide antibiotic. It is a major intermediate of sulfamethoxazole biodegradation. It also functions as a carbonic anhydrase inhibitor and exhibits inhibition against the virus of lymphogranuloma venereum.
Potent anti-infection activity in albino mice
Inhibits HepG2 cells with an IC50 of 0.08 μM
Inhibits K562 cells with an IC50 of 0.2 μM
Inhibits MDA-MB-231 cells with an IC50 of 0.09 μM
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