Sulfonamide antibacterial Sulfanilamide is an antibacterial and used in the treatment of vaginal yeast infections It is a competitive inhibitor of dihydropteroate synthestase to block the synthesis of folic acid It serves as an intermediate for the preparation of 26-disubstituted anilines by electrophilic substitution followed by removal of the sulfonamide blocking group by desulfonation with sulfuric acid
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INCB024360 analogue (CAS 914471-09-3) is a selective inhibitor of indoleamine 2 3-dioxygenase 1 (IDO1) an enzyme responsible for initiating tryptophan catabolism along the kynurenine pathway IDO1-mediated depletion of tryptophan in the tumor microenvironment can suppress T-cell proliferation and promote immune tolerance facilitating cancer immune evasion INCB024360 analogue inhibits human IDO1 with an IC50 of 67 nM and demonstrates minimal activity against the related enzyme TDO In vivo studies in mouse melanoma models reveal dose-dependent anti-tumor activity and significant reductions in kynurenine levels supporting its utility as a research tool to investigate IDO1-targeted immunotherapy strategies
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