Organosulfur Compounds
AdipoGen Vandetanib
Chemical. CAS 443913-73-3. Formula C22H24BrFN4O2. MW 475.4. Vandetanib is an orally available, ATP mimetic small molecule tyrosine kinases inhibitor that targets vascular endothelial growth factor receptor-2 VEGFR-2, VEGFR-3 and epidermal growth factor receptor EGFR, REarranged during Transfection RET and slightly VEGFR-1. Inhibition of these tyrosine kinases blocks multiple intracellular signaling pathways involved in tumor growth, proliferation, progression and angiogenesis. It inhibits RET, VEGFR2, VEGFR3, VEGFR1, EGFR, PDGFRbeta, Tie-2, and FGFR1 in cell-free assays IC50s = 34, 40, 110, 1,600, 500, 1,100, 2,500, and 3,600 nM, respectively. It also binds to 142 additional kinases in a panel of 442 kinases Kds = 4.6-7,900 nM. Vandetanib 1 and 2.5 µM induces apoptosis, autophagy, ROS and cell cycle arrest at the G0/G1 phase and has anti-proliferative properties in several cancer cell lines and in in vivo cancer models.
Medchemexpress LLC Cyclopropylmethyl bromide | 7051-34-5 | MFCD00001306 | 99.2% | 135.00 g/mol | C4H7Br | 50g
Cyclopropylmethyl bromide is an intermediate Cyclopropylmethyl bromide can be used in the preparation of Firocoxib (HY-14670) Firocoxib (ML 1785713) is a potent selective orally active COX-2 inhibitor[1]
Apexbio Technology LLC TUG-770 1402601-82-4 5mg
TUG-770 (CAS 1402601-82-4) is a potent agonist of the free fatty acid receptor 1 (FFA1/GPR40) a G protein-coupled receptor implicated in the enhancement of glucose-stimulated insulin secretion by pancreatic -cells TUG-770 demonstrates high affinity for FFA1 with an EC50 of 6 nM and over 150-fold selectivity compared to FFA4 as well as high selectivity over other receptors and transporters In INS-1E rat -cell lines TUG-770 promotes insulin secretion in the presence of elevated glucose Pharmacokinetic studies in mice indicate favorable oral absorption and bioavailability with dose-dependent reductions in blood glucose during glucose tolerance tests TUG-770 is a valuable tool for investigating FFA1-mediated pathways and glucose homeostasis in metabolic research
eMolecules Medchem Express / DL-Homocystine-33334444-d8 / 5mg / 771359132 / HY-W009390S / / 108641-82-3 / MFCD00209738 / 276.390 / C8H16N2O4S2
Medchem Express / DL-Homocystine-33334444-d8 / 5mg / 771359132 / HY-W009390S / / 108641-82-3 / MFCD00209738 / 276.390 / C8H16N2O4S2
Cayman Chemical Diallyl Disulfide
An organosulfur compound derived from allicin; converted, in the presence of thiols, to the gaseous mediator H2S; serves as a thiol-dependent H2S donor in biological systems
Apexbio Technology LLC Sulfanilamide,10g CAS# 63-74-1
Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM. Other sizes are also available. Please inqury us for quote.
eMolecules AstaTech / TETRAHYDROTHIOPHEN-3-AMINE / 0.05g / 789361514 / 70834 / 95.000 / 101993-01-5 / MFCD00120988 / 103.180 / C4H9NS
AstaTech / TETRAHYDROTHIOPHEN-3-AMINE / 0.05g / 789361514 / 70834 / 95.000 / 101993-01-5 / MFCD00120988 / 103.180 / C4H9NS
eMolecules 5,6-Dimethyl-2-thiouracil | 28456-54-4 | MFCD00278872 | 25g
Combi-Blocks | 5,6-Dimethyl-2-thiouracil | 25g | 401038904 | QJ-2954 | 97.000 | 28456-54-4 | MFCD00278872 | 156.200 | C6H8N2OS
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Sigma Aldrich Fine Chemicals Biosciences DL-Sulforaphane | 4478-93-7 | MFCD00198068 | 5 mg
DL-Sulforaphane | Purity: 90% | Mol Wt: 177.29 | 4478-93-7 | MFCD00198068 | 5 mg
Medchemexpress LLC N N-Dicyclohexyl-2-b 100g
N N-Dicyclohexyl-2-benzothiazolesulfenamide is a compound with reproductive and developmental toxicity that can affect body weight gain reproductive organ weight and multiple reproductive and developmental indicators in rats