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Sulindac (CAS 38194-50-2) is a nonsteroidal anti-inflammatory drug that functions as a prodrug and is metabolized in vivo to pharmacologically active sulindac sulfide and sulindac sulfone Sulindac sulfide acts as a cyclooxygenase inhibitor and modulates intracellular signaling pathways including the repression of ras activity Sulindac sulfone possesses antitumor properties independent of cyclooxygenase inhibition Due to these distinct metabolites and their activities sulindac is utilized in biomedical research for studying inflammatory processes cyclooxygenase-mediated pathways and the chemopreventive mechanisms involved in tumorigenesis
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(Cyclohexanecarbonyl)-L-leucine is a cyclohexanecarbonyl-protected derivative of the amino acid L-leucine supplied as a research reagent. It is provided as a white to off-white solid with defined purity and storage recommendations for laboratory use.
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