Organosulfur Compounds
Medchemexpress LLC MedChemExpress KRAS G12D Inhibitor, Zoldonrasib, Potent, Orally Active, Solid
Zoldonrasib (RMC-9805) is a potent and orally active KRAS G12D inhibitor. It induces apoptosis in KRAS G12D mutant cancer cells and has potential for the research of KRAS G12D mutant cancer.
- Potent KRAS G12D inhibitor
- Orally active
- Induces apoptosis in KRAS G12D mutant cancer cells
- Potential for research of KRAS G12D mutant cancer
- Inhibits CXCL1 and GM-CSF production in eCT26 (KRASG12D/G12D) cells
- Shows antitumor activity in KRAS G12D xenograft models
- Decreases myeloid cells and increases cytotoxic T cells in mice
- Solid appearance
- White to yellow color
eMolecules 184162-48-9 | 4-(DIFLUOROMETHOXY)-3-FLUOROPHENOL | MFCD18395029 | 1g
Medchem Express | JQKD82 (trihydrochloride) | 5mg | 719835977 | HY-138691A | 2863676-87-1 | 610.010 | C27H43Cl3N4O5
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eMolecules 1211581-51-9 | 2-(Difluoromethoxy)isonicotinic acid | MFCD18258474 | 1g
ChemScene | (3-Methoxy-2-methylphenyl)boronic acid | 100mg | 536805695 | CS-0101369 | 1313617-76-3 | MFCD18398348 | 165.980 | C8H11BO3
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![eMolecules 57090-88-7 | 1H-Imidazole-4-carbonitrile | Synthonix | MFCD00233358 | 93.089 | C4H3N3 | 97.000 | N#Cc1c[nH]cn1 | 100mg | 649427214](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000190339.jpg-250.jpg)
eMolecules 57090-88-7 | 1H-Imidazole-4-carbonitrile | Synthonix | MFCD00233358 | 93.089 | C4H3N3 | 97.000 | N#Cc1c[nH]cn1 | 100mg | 649427214
1H-Imidazole-4-carbonitrile | Synthonix | 57090-88-7 | MFCD00233358 | 93.089 | C4H3N3 | 97.000 | N#Cc1c[nH]cn1 | 100mg | 649427214
eMolecules 2-(Difluoromethoxy)-3-fluoroaniline | 153468-97-4 | MFCD14698441 | 1g
Apollo Scientific | 2-(Difluoromethoxy)-3-fluoroaniline | 1g | 562428325 | PC501999 | | 153468-97-4 | MFCD14698441 | 177.126 | C7H6F3NO
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Medchemexpress LLC Pyrazine-2-carbonitrile | 19847-12-2 | MFCD00049361 | 100.0% | 105.10 | C5H3N3 | 500g
Pyrazine-2-carbonitrile is a biochemical reagent that can be used as a biological material or organic compound for life science related research
eMolecules 1300750-50-8 | (2-(Difluoromethoxy)pyridin-3-yl)boronic acid | MFCD18261901 | 1g
ChemScene | 3-(1h-Indol-3-yl)-2-methylpropanoic acid | 100mg | 714177170 | CS-0275891 | 15142-91-3 | MFCD01860840 | 203.241 | C12H13NO2
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Apexbio Technology LLC TUG-770 1402601-82-4 5mg
TUG-770 (CAS 1402601-82-4) is a potent agonist of the free fatty acid receptor 1 (FFA1/GPR40) a G protein-coupled receptor implicated in the enhancement of glucose-stimulated insulin secretion by pancreatic -cells TUG-770 demonstrates high affinity for FFA1 with an EC50 of 6 nM and over 150-fold selectivity compared to FFA4 as well as high selectivity over other receptors and transporters In INS-1E rat -cell lines TUG-770 promotes insulin secretion in the presence of elevated glucose Pharmacokinetic studies in mice indicate favorable oral absorption and bioavailability with dose-dependent reductions in blood glucose during glucose tolerance tests TUG-770 is a valuable tool for investigating FFA1-mediated pathways and glucose homeostasis in metabolic research
![Medchemexpress LLC Imidazo[1,2-a]pyrazine | 274-79-3 | 119.13 | 5 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000404081-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Imidazo[1,2-a]pyrazine | 274-79-3 | 119.13 | 5 G
Imidazo[1,2-a]pyrazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is intended for research use only and is not sold to patients.
- Appearance: solid, light yellow to light brown color
- Shipping: room temperature in continental US
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
- Solubility: DMSO: 100 mg/mL (839.44 mM), ultrasonic treatment may be needed