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INCB024360 analogue (CAS 914471-09-3) is a selective inhibitor of indoleamine 2 3-dioxygenase 1 (IDO1) an enzyme responsible for initiating tryptophan catabolism along the kynurenine pathway IDO1-mediated depletion of tryptophan in the tumor microenvironment can suppress T-cell proliferation and promote immune tolerance facilitating cancer immune evasion INCB024360 analogue inhibits human IDO1 with an IC50 of 67 nM and demonstrates minimal activity against the related enzyme TDO In vivo studies in mouse melanoma models reveal dose-dependent anti-tumor activity and significant reductions in kynurenine levels supporting its utility as a research tool to investigate IDO1-targeted immunotherapy strategies
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
COP1-ATGL modulator 1 is an orally active small-molecule research reagent that modulates the COP1-ATGL pathway. It increases ATGL protein expression, reduces ATGL and COP1 ubiquitination, and diminishes lipid accumulation in hepatocytes at nanomolar concentrations. Supplied as a white to off-white solid with high purity and defined storage recommendations for powder and solution.
Orally active modulator of COP1-ATGL signaling.
Increases ATGL protein expression at nanomolar concentrations.
Reduces ATGL and COP1 ubiquitination in cellular assays.
High purity suitable for research applications.
Stable solid with recommended low-temperature storage.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More