Phenylpropanoids and polyketides
Curcumin (Synthetic) 97.0+%, TCI America™
CAS: 458-37-7 Molecular Formula: C21H20O6 Molecular Weight (g/mol): 368.39 MDL Number: MFCD00008365 InChI Key: ZIUSSTSXXLLKKK-KOBPDPAPSA-N Synonym: curcumin,diferuloylmethane,natural yellow 3,turmeric yellow,turmeric,curcuma,kacha haldi,gelbwurz,halad,curcumin i PubChem CID: 969516 ChEBI: CHEBI:3962 IUPAC Name: (1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one SMILES: COC1=CC(\C=C\C(\O)=C\C(=O)\C=C\C2=CC=C(O)C(OC)=C2)=CC=C1O
Chem-Impex International, Inc. Curcumin | 458-37-7 | MFCD00008365 | 25G
Curcumin, 458-37-7, MFCD00008365, 25G
Medchemexpress LLC Curcumin | 458-37-7 | 98.6% | 10 MM * 1 ML
Curcumin | 458-37-7 | 98.6% | 10 MM * 1 ML
Sigma Aldrich Fine Chemicals Biosciences Curcumin from Curcuma longa (Turmeric), powder | 458-37-7 | MFCD00008365 | 10g
Curcumin from Curcuma longa (Turmeric), powder | Purity: 65% | 368.38 | 458-37-7 | MFCD00008365 | 10g
Sigma Aldrich Fine Chemicals Biosciences Curcumin from Curcuma longa (Turmeric), powder | 458-37-7 | MFCD00008365 | 5G
Curcumin from Curcuma longa (Turmeric), powder | Purity: >=65% (HPLC) | Mol Wt: 368.38 | 458-37-7 | MFCD00008365 | 5G
Apexbio Technology LLC Curcumin(Synonyms: Diferuloylmethane, Turmeric yellow, Natural yellow 3, CI 75300), 100mg, CAS: 458-37-7.
Curcumin (CAS 458-37-7) is a natural small molecule known to inhibit tyrosinase activity with an IC50 of 47 M It modulates multiple signaling pathways involved in tumorigenesis and inflammation influencing transcription factors growth factors cytokines receptors and enzymes Clinical trials at Phase I reported no observed toxicity at doses up to 12 g/day however oral bioavailability is limited ( 1% in Phase I/II studies) Additionally curcumin demonstrates potential for Alzheimer s research as evidenced by reducing beta-amyloid (A 40 A 42) production via downregulating presenilin-1 and GSK-3 in SH-SY5Y neuroblastoma cells
Apexbio Technology LLC Curcumin(Synonyms: Diferuloylmethane, Turmeric yellow, Natural yellow 3, CI 75300), 10mM (in 1mL DMSO), CAS: 458-37-7.
Curcumin (CAS 458-37-7) is a natural small molecule known to inhibit tyrosinase activity with an IC50 of 47 M It modulates multiple signaling pathways involved in tumorigenesis and inflammation influencing transcription factors growth factors cytokines receptors and enzymes Clinical trials at Phase I reported no observed toxicity at doses up to 12 g/day however oral bioavailability is limited ( 1% in Phase I/II studies) Additionally curcumin demonstrates potential for Alzheimer s research as evidenced by reducing beta-amyloid (A 40 A 42) production via downregulating presenilin-1 and GSK-3 in SH-SY5Y neuroblastoma cells
Medchemexpress LLC 1,6-heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)- | 458-37-7 | MFCD00008365 | 97.3% | 368.38 g·mol^-1 | C21H20O6 | 10 MG
Curcumin (diferuloylmethane) is a natural phenolic research reagent that functions as a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase. It modulates NF-κB and MAPK pathways, stabilizes Nrf2 through Keap1 cysteine modification, and exhibits anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic activities. Supplied as a characterized powder with recommended storage conditions and a COA.
AdipoGen Curcumin
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.38. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4, tumorigenesis and development Shh, Gli, metabolism PPARgamma, Nrf2, epigenetics HDACs, HATs, DNA methyltransferase I and microRNAs and inflammation NLRP3, TLR4, NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX.
AdipoGen Curcumin
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.38. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4, tumorigenesis and development Shh, Gli, metabolism PPARgamma, Nrf2, epigenetics HDACs, HATs, DNA methyltransferase I and microRNAs and inflammation NLRP3, TLR4, NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX.
AdipoGen Curcumin high purity
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.4. Synthetic. Originally isolated from turmeric Curcuma longa. Anti-cancer compound. Interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4 and inflammation NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX. Anti-angiogenic. Anti-metastatic. Anti-invasive. Chemopreventive. Sonic hedgehog Shh signaling pathway modulator. Downregulates Shh and Gli1. Antioxidant. Anti-inflammatory. Potent inhibitor of NF-kappaB, cyclooxygenase-2 COX-2, lipooxygenase LOX, and inducible nitric oxide synthase iNOS NOSII. Downregulates the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12 and chemokines. Potent immunomodulator.