Elemental Metals

Medchemexpress LLC γ1-MSH | 72629-65-3 | 99.6% | 1512.74 | 1 MG

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γ1-MSH is a potent melanocortin MC3 receptor agonist, exhibiting a Ki of 34 nM for the rat MC3 receptor. This compound demonstrates approximately 40-fold selectivity over MC4, with a Ki of 1318 nM.

• Melanocortin MC3 receptor agonist
• Ki of 34 nM for the rat MC3 receptor
• Displays ~40-fold selectivity over MC4 (Ki=1318 nM)
• Solid appearance
• White to off-white color
• Sequence shortening: YVMGHFRWDRF-NH2
• Recommended storage for powder: -80°C for 2 years, -20°C for 1 year (sealed, away from moisture)
• Recommended storage in solvent: -80°C for 6 months, -20°C for 1 month (sealed, away from moisture)

Medchemexpress LLC γ1-MSH | 72629-65-3 | 99.6% | 1512.74 g/mol | 5 MG

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Small and/or specialty supplier based on Federal laws and SBA requirements.
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γ1-MSH is a melanocortin MC3 receptor agonist with a Ki of 34 nM for the rat MC3 receptor. It displays approximately 40-fold selectivity over MC4 (Ki=1318 nM).

• Molecular weight of 1512.74
• Chemical formula is C72H97N21O14S
• CAS number is 72629-65-3
• Appears as a solid
• Color is white to off-white
• Sequence shortening: YVMGHFRWDRF-NH2
• Ships at room temperature in continental US; may vary elsewhere
• Store sealed and away from moisture: powder at -80°C for 2 years or -20°C for 1 year; in solvent at -80°C for 6 months or -20°C for 1 month

Apexbio Technology LLC TH-302 918633-87-1 10mM (in 1mL DMSO)

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TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity