Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Medchemexpress LLC MRTX-EX185 formic | 2988148-70-3 | 97.23% | C34H35FN6O4 | 1 MG
MRTX-EX185 formic is a potent KRAS (G12D) inhibitor (IC50 of 90 nM) that binds to both GDP-loaded and active GNP states of KRAS. It exhibits broad-spectrum binding properties and is used for studying various RAS-driven tumors, such as pancreatic cancer.
- Potent KRAS (G12D) inhibitor with IC50 of 90 nM
- Binds to GDP-loaded and active GNP states of KRAS and KRAS (G12D)
- Exhibits broad-spectrum binding properties including for KRAS WT, G12C, Q61H, G13D, and HRAS
- Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells (IC50 = 70 nM)
- Non-toxic to non-KRAS-dependent HEK293 cells
- Significantly inhibits ERK phosphorylation in KRAS(G12C)-driven cell lineages
Sigma Aldrich Fine Chemicals Biosciences Formic acid | 64-18-6 | MFCD00003297 | 500 mL
Formic acid | Purity: 96% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 500 mL
Sigma Aldrich Fine Chemicals Biosciences Formic acid puriss. p.a., ACS reagent, reag. Ph. Eur., >=98% | 64-18-6 | MFCD00003297 | 500ML
Formic acid puriss. p.a., ACS reagent, reag. Ph. Eur., >=98% | Purity: >=98% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 500ML
TARGETMOL CHEMICALS INC BMS-561392 FORMIC ACID 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BMS-561392 Formic acid is a selective inhibitor of TACE and reduces TNFalpha levels.
Cambridge Isotope Laboratories FORMIC ACID (OD, 98%) (, 5 G, 1925-94-0
FORMIC ACID (OD, 98%) (, 5 G, 1925-94-0
Sigma Aldrich Fine Chemicals Biosciences Formic acid puriss., meets analytical specifications of DAC, FCC, 98.0-100% | 64-18-6 | MFCD00003297 | 1L
Formic acid puriss., meets analytical specifications of DAC, FCC, 98.0-100% | Purity: 98.0-100% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 1L
U.S. Pharmacopeia Formic Acid (1.2 mL/ampule; 3 ampules) | 64-18-6 | MFCD00003297
Formic Acid (1.2 mL/ampule; 3 ampules) | Mol Wt: 46.025 | 64-18-6 | MFCD00003297 |
Medchemexpress LLC Slb1122168 formic | 2999629-17-1 | 99.9% | 403.56 | C23H37N3O3 | 10 MG
SLB1122168 formic is a research-stage small molecule that inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release. It has reported in vitro potency and is supplied for laboratory research with recommended storage and handling per the Safety Data Sheet.
eMolecules Ambeed / Ammonium formate / 25g / 506390793 / A414767 / / 540-69-2 / MFCD00013103 / 63.056 / CH5NO2
Ambeed / Ammonium formate / 25g / 506390793 / A414767 / / 540-69-2 / MFCD00013103 / 63.056 / CH5NO2
eMolecules Oakwood Chemicals Formic Acid ACS Grade 20kg 480143866 093996 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Oakwood Chemicals Formic Acid ACS Grade 20kg 480143866 093996 0 000 64-18-6 MFCD00003297 46 025 CH2O2
eMolecules Oakwood Chemicals Formic Acid 1kg 480142339 080324 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Oakwood Chemicals Formic Acid 1kg 480142339 080324 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Sigma Aldrich Fine Chemicals Biosciences Formic acid ACS reagent, >=88% | 64-18-6 | MFCD00003297 | 2.5L
Formic acid ACS reagent, >=88% | Purity: >=88% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 2.5L
LifeSensors Ubiquitin Mass Spectrometry Kit
Mass spectrometry (MS) proteomics, especially when combined with TUBE technologies for protein enrichment, can be used in several innovative and impactful applications. Quantitatively profiling the ubiquitome can lead to the identification of ubiquitination sites on target proteins, and by extension unveiling the mechanisms of undiscovered E3 ligases with their substrates. MS can also inform small molecule drug discovery for these targets (e.g. PROTACs, molecular glues) by quantitatively reporting on how much target protein is degraded in the presence or absence of a drug candidate. This approach can also greatly aid the discovery and development of novel diagnostic biomarkers for challenging disease targets and development of clinically monitoring disease progression. All these applications require a simple, label-free, rapid ubiquitome approach. This kit is designed to address this for rapid yet reproducible proteomics. *The plate is designed for research use only.