Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC M65 TFA | 99.98% | 4823.53 (free base) | 1 MG
M65 TFA is a deleted peptide of maxadilan (61 a.a.) with a deletion of residues between positions 24 and 42. It acts as a specific antagonist of the PACAP type 1 receptor, inhibiting ANP secretion, and can be utilized for relevant research purposes.
- Specific antagonist of the PACAP type 1 receptor.
- Inhibits ANP secretion.
- Suitable for research.
- In vitro activity: M65 (1 μM) completely blocks cAMP accumulation stimulated by 100 nM of VIP and partially inhibits cAMP accumulation stimulated by 1 nM of maxadilan in rat cortical neurons.
Medchemexpress LLC Ant308 (TFA) | 99.6% | 3467.10 | 5 MG
ANT308 TFA is a vasoactive intestinal polypeptide (VIP receptor) antagonist. It significantly enhances the activation and proliferation of T cells, inhibits migration and metastasis, and induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of MCAM and N-cadherin. It can be used for the study of acute myeloid leukemia (AML) and uveal melanoma (UVM).
- Reduces the viability of specific cell lines
- Decreases the proportion of cells in the S phase
- Induces apoptosis in certain cell types
- Inhibits cell migration in multiple cell lines
- Reduces MCAM and N-cadherin expression
- Reduces the number and size of liver metastases in animal models
- Shows a trend toward reducing tumor volume in primary tumor sites in animal models
Medchemexpress LLC Gsnkskpk-nh2 (TFA) | 99.9% | 843.97 (free base) | 5 MG
GSNKSKPK-NH2 TFA is a model peptide based on a c-Src N-terminal peptide, which serves as an NMT substrate.
- Purity: 99.9%
- Appearance: White to off-white solid
- Sequence: Gly-Ser-Asn-Lys-Ser-Lys-Pro-Lys-NH2
- Molecular formula: C35H65N13O11.xC2HF3O2
- Soluble in water and DMSO
Apexbio Technology LLC 10 mM dNTP Mixture 5x1ml
10 mM dNTP (2 -deoxynucleoside 5 -triphosphate) Mixture is an equimolar premixed aqueous solution containing four nucleotides (dATP dCTP dGTP and dTTP) each at a concentration of 10 mM The product is prepared as an aqueous solution titrated with NaOH to a neutral pH of 7 0
Apexbio Technology LLC 5-hme-CTP 10x100ul (100 mM)
5-hme-CTP (5-hydroxymethylcytidine triphosphate) is a modified cytidine triphosphate bearing a hydroxymethyl group at the 5-position carbon This modification can enhance RNA stability and functionality During in vitro mRNA synthesis 5-hme-CTP can be incorporated into RNA molecules producing RNA containing 5-hydroxymethylcytidine Hydroxymethyl-modified RNA plays an essential role in studying RNA structure function and RNA-protein interactions Additionally 5-hme-CTP significantly improves RNA stability by reducing its intracellular degradation Thus this modified nucleotide has broad applications in gene expression research RNA-based drug development and gene therapy
Medchemexpress LLC Gln-AMS TFA | 99.85% | 588.47 | 50 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. It specifically inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. This product is intended for research use only.
- Inhibits glutaminyl-tRNA synthetase.
- High purity of 99.85%.
- Available in various quantities.
- Data sheet, COA, SDS, and handling instructions provided.
- Supported by customer reviews and publications.
Medchemexpress LLC Retatrutide TFA 10mg
Retatrutide, (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity. 10mg
Medchemexpress LLC BIM 23042 trifluoroacetate | 00-00-0 | 96.2% | 1192.45 g/mol (free base) | C63H73N11O9S2.xC2HF3O2 | 5 MG
BIM 23042 TFA is a somatostatin-like octapeptide analogue that functions as a selective antagonist of the neuromedin B receptor (NMB-R/BB1). Supplied as the trifluoroacetate (TFA) salt at high purity, it is intended for research use in receptor pharmacology and related biochemical assays.
- Selective antagonist of neuromedin B receptor (BB1).
- TFA salt form for improved handling and stability.
- High purity suitable for receptor pharmacology and calcium mobilization assays.
- Supplied as a small, lyophilized quantity for laboratory research use.
- Molecular weight and elemental composition available in the product documentation.
Medchemexpress LLC Lys-bradykinin trifluoroacetate | 00-00-0 | 99.9% | 1188.38 g/mol | C56H85N17O12·xC2HF3O2 | 100 MG
Lys-Bradykinin TFA is the trifluoroacetate salt of the decapeptide kallidin (Lys-bradykinin), supplied as a purified peptide powder for laboratory research. It acts as a ligand for kallidin and bradykinin receptors and is involved in vascular regulation, inflammation, and pain signaling.
- TFA salt of Lys-bradykinin (kallidin).
- Decapeptide sequence: Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg.
- High purity (99.9%).
- Molecular weight 1188.38 g/mol (free base).
- Storage: powder - sealed, away from moisture and light; powder storage: -80°C for 2 years, -20°C for 1 year.