Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Covachem Trifluoroacetic Acid | 76-05-1 | MFCD00004169 | 10 x 1 mL
This item has a minimum order quantity of 2 per supplier requirements.
Trifluoroacetic Acid | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 10 x 1 mL
Medchemexpress LLC Galnon TFA | 1217448-19-5 | MFCD06798339 | 98.9% | 792.84 | C42H47F3N4O8 | 5 MG
Galnon TFA is a selective, non-peptide agonist of galanin receptors GAL1 and GAL2 used in neuroscience research. It binds GAL1 and GAL2 with reported Kis of 11.7 μM and 34.1 μM and has demonstrated anticonvulsant and anxiolytic effects. The compound is supplied as a white to off-white solid with high purity and is soluble in DMSO for in vitro use.
- Selective galanin receptor agonist (GAL1 and GAL2).
- Demonstrated anticonvulsant and anxiolytic activity in preclinical models.
- High purity (98.9%) and white to off-white solid appearance.
- Soluble in DMSO (125 mg/mL); use fresh DMSO and ultrasonic assistance if needed.
- Recommended storage sealed, protected from moisture and light; frozen solution stability varies by temperature.
Medchemexpress LLC FLAG peptide TFA | 99.6% | 1012.97 | 5 MG
FLAG peptide TFA is the trifluoroacetic acid salt form of FLAG peptide, often denoted as HY-P0223. It functions as a versatile fusion tag specifically designed for the purification of recombinant proteins. This peptide plays a crucial role in maintaining the natural, functional folding of the proteins it is fused with, ensuring their biological activity. It can be efficiently removed by enterokinase and is capable of being eluted under non-denaturing conditions, which is beneficial for preserving protein integrity.
- Multifunctional fusion tag
- Used for purification of recombinant proteins
- Maintains natural folding of fusing proteins
- Can be removed by enterokinase
- Eluted under non-denaturing conditions
Medchemexpress LLC Cys-TAT(47-57) TFA | 98.1% | 1661.99 | 5 MG
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein.
- Appearance: Solid
- Color: White to off-white
- Sequence: Cys-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
- Shipping: Room temperature in continental US
- Storage (powder): -80°C for 2 years, -20°C for 1 year (sealed, away from moisture and light, under nitrogen)
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month (sealed, away from moisture and light, under nitrogen)
- Solubility (H2O): 100 mg/mL (needs ultrasonic)
- Solubility (DMSO): ≥ 100 mg/mL
- Related classifications: Peptides, Peptide and derivatives, Peptides for drug delivery, Cell-penetrating peptides
- Disease areas: Infection, Anti-infection HIV
Medchemexpress LLC Liraglutide TFA | 99.6% | 3751.20 | 5 MG
Liraglutide (TFA) is an agonist of the glucagon-like peptide 1 receptor (GLP-1). It can activate GLP-1, resulting in the release of insulin when glucose concentration is elevated. Additionally, Liraglutide (TFA) reduces glucagon secretion in a glucose-dependent manner and can be utilized in research concerning type 2 diabetes.
- Agonist of glucagon-like peptide 1 receptor (GLP-1)
- Activates GLP-1, which leads to insulin release in the presence of increased glucose concentration
- Reduces glucagon secretion in a glucose-dependent manner
- Can be studied in research on type 2 diabetes
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus(R), 99% | 76-05-1 | MFCD00004169 | 2L
Trifluoroacetic acid ReagentPlus(R), 99% | Purity: 99% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 2L
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus(R), 99% | 76-05-1 | MFCD00004169 | 1AMP
Trifluoroacetic acid ReagentPlus(R), 99% | Purity: 99% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 1AMP
Proteochem Inc TFA Ampules (Proteomics Grade), 76-05-1, MFCD00004169, 10x1 g
MF: C2 H F3 O2, MW: 114.03, Alternative Names: TFA Ampoules; Trifluoroacetic Acid Ampoules; TFA Amps. Trifluoroacetic acid (TFA) is an effective ion pairing agent for HPLC and proteomics LCMS applications which are regularly used to resolve chromatographically similar analytes.
Medchemexpress LLC Llvk tfa | 585.66 | 5 MG
LLVK TFA is a selective IκB phosphorylation inhibitor. It reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), making it promising for research of inflammatory bowel disease and rheumatoid arthritis.
- Selective IκB phosphorylation inhibitor
- Reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α)
- Promising for research of inflammatory bowel disease
- Promising for research of rheumatoid arthritis
Medchemexpress LLC D-GsMTx4 TFA | 99.9% | 4095.84 | 100 UG
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4. It inhibits the mechanosensitive ion channel Piezo2, [Ca2+]i elevation, and mTOR and PI3K-Akt signaling pathways. This compound can inhibit mechanical allodynia and thermal hyperalgesia.
- Inhibits the mechanosensitive ion channel Piezo2.
- Inhibits intracellular calcium elevation.
- Inhibits mTOR and PI3K-Akt signaling pathways.
- Can be used in research related to mechanical stress.
- Useful for studies on chronic pain and idiopathic pulmonary fibrosis.