Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC IA9 TFA (human TREM-2 182-190 TFA) | 98.9% | 1001.31 (free acid) | 5 MG
IA9 TFA is a potent, CNS-penetrant inhibitor of Triggering Receptor Expressed on Myeloid cells 2 (TREM-2). It is capable of reducing proinflammatory cytokines and mitigating joint inflammation and damage in a Collagen-induced arthritis mouse model. This compound is suitable for neuroinflammation PET imaging and research related to rheumatoid arthritis and neuroinflammation.
Features and Benefits
- Potent CNS-penetrant TREM-2 inhibitor.
- Diminishes the release of proinflammatory cytokines.
- Suppresses joint inflammation and damage in experimental arthritis.
- Can be used for neuroinflammation PET imaging.
- Applicable for rheumatoid arthritis and neuroinflammation research.
Medchemexpress LLC Ss47 Tfa | 2636072-62-1 | 99.88% | 1067.09 | 1 MG
SS47 TFA is a PROTAC-based HPK1 degrader that facilitates proteasome-mediated HPK1 degradation. This significantly improves in vivo antitumor efficacy in BCMA CAR-T cell research. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies. SS47 (TFA) is also a click chemistry reagent with an Alkyne group, capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc).
- PROTAC-based HPK1 degrader
- Facilitates proteasome-mediated HPK1 degradation
- Enhances in vivo antitumor efficacy in BCMA CAR-T cell research
- Targets HPK1, an immunosuppressive regulatory kinase
- Click chemistry reagent with alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC LIH383 TFA | 2866266-58-0 | 99.8% | 997.22 | 5 MG
LIH383 TFA is a white to off-white solid that has been tested and complies with specifications, exhibiting a high purity of 99.83% by HPLC.
- Tested and complies with specifications
- High purity of 99.83% (HPLC)
- White to off-white solid appearance
- Store in sealed conditions away from moisture
- Powder stable for 2 years at -80°C or 1 year at -20°C
- In solvent, stable for 6 months at -80°C or 1 month at -20°C
Medchemexpress LLC Rsm3 Tfa | 98.8% | 3049.66 | 1 MG
This product is a stapled peptide that acts as an inhibitor of METTL3-METTL14, with a Kd of 3.10 μM. It has been shown to inhibit tumor growth and induce cell apoptosis, making it useful for cancer research.
- It is a stapled peptide.
- It is a METTL3-METTL14 inhibitor.
- It inhibits tumor growth.
- It induces cell apoptosis.
- It is suitable for cancer research.
Medchemexpress LLC Dendrotoxin-I (TFA) | 99.9% | 7149.24 | 5 MG
Dendrotoxin-I (DTX-I) TFA is a potent K+ channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6. This neurotoxin has potential for cancer research.
- Potent K+ channel blocker.
- Targets voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6.
- Potential for cancer research.
- Shows significant tumor growth inhibition effect in nude mice with MCF-7 cells when combined with hyperthermia (at 5 mg/kg IV).
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 25G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 25G
Medchemexpress LLC 7-TFA-ap-7-Deaza-dA | 178420-75-2 | 98.8% | 399.32 | 1 ML
7-TFA-ap-7-Deaza-dA is a modified nucleoside that can be used in the synthesis of deoxyribonucleic acid or nucleic acid. It functions as a click chemistry reagent, containing an alkyne group that undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Modified nucleoside.
- Can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
- Functions as a click chemistry reagent.
- Contains an alkyne group for reactions.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
Medchemexpress LLC JPS014 TFA | 98.12% | C48H60F3N7O9S | 25 MG
JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC). It degrades class I histone deacetylase (HDAC) and is a potent HDAC1/2 degrader. This degradation correlates with a greater number of total differentially expressed genes and enhanced apoptosis in HCT116 cells.
- Benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC)
- Degrades class I histone deacetylase (HDAC)
- Potent HDAC1/2 degrader
- Correlates with greater total differentially expressed genes
- Enhances apoptosis in HCT116 cells
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic Acid | CAS 76-05-1
Trifluoroacetic Acid | Purity: >=99.0% | M. W.: 114.02 | 76-05-1 | 200-929-3
Medchemexpress LLC Glycyl-exatecan (TFA) | 1883333-57-0 | 96.9% | 100 MG
Glycyl-Exatecan TFA is a derivative of Exatecan, known for its significant antitumor activity. This compound acts as an anticancer agent and is suitable for research applications, particularly in studies involving solid tumors.
- Acts as an anticancer agent
- Exhibits significant antitumor activity
- Suitable for solid tumors research
- Derivative of Exatecan
Medchemexpress LLC Flonoltinib TFA | 2928093-29-0 | >98.0% | 1 ML
Flonoltinib TFA is a potent and orally active dual JAK2/FLT3 inhibitor with anti-cancer activity, designed for research applications.
- Potent and orally active dual JAK2/FLT3 inhibitor.
- Exhibits anti-cancer activity.
- Down-regulates p-FLT3 in a dose-dependent manner.
- Induces apoptosis and cell cycle arrest in MV4-11 cells.
Medchemexpress LLC Glycyl-exatecan TFA | 1883333-57-0 | 96.9% | 606.52 g/mol | C28H26F4N4O7 | 5 MG
Glycyl-exatecan TFA is a synthetic trifluoroacetate salt derivative of exatecan used as an experimental anticancer compound in research. It is supplied in solid and DMSO solution formats for in vitro and in vivo pharmacology studies; consult supplier documentation and the SDS for handling and storage guidelines.
- Trifluoroacetate salt form.
- Molecular formula C28H26F4N4O7.
- Molecular weight 606.52 g/mol.
- Purity typically around 96.9%.
- Available in small-scale sizes and 10 mM DMSO solutions.
- Intended for research use only in oncology and pharmacology.
- Handle according to SDS and laboratory safety procedures.