Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC EZM0414 TFA | 2411759-92-5 | 95.5% | 514.51 | 1 MG
EZM0414 TFA is the TFA salt form of EZM0414, a potent, selective, and orally active inhibitor of SETD2. It is characterized by an IC50 of 18 nM in the SETD2 biochemical assay and 34 nM in the cellular assay. This compound is suitable for research into relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent, selective, orally active inhibitor of SETD2
- Inhibits proliferation of multiple myeloma and diffuse large B-cell lymphoma cell lines
- Inhibits tumor growth in NOD SCID mouse xenograft models
- Shows robust tumor growth regressions in t(4;14) multiple myeloma cell line-derived xenograft models
- Associated with reductions in intratumoral H3K36me3 levels
- Demonstrates high oral bioavailability in rats and mice
- Well-tolerated in animal studies
Medchemexpress LLC NH2-UAMC1110 TFA | 2990021-73-1 | 99.9% | 545.46 g·mol⁻¹ | C23H24F5N5O5 | 10 MG
NH2-UAMC1110 TFA is the trifluoroacetic acid salt of an amino-functionalized derivative of UAMC1110. It is used as a chemical intermediate for the synthesis of FAPI-QS and other FAP-targeting imaging agents and radiotracers. The compound is supplied with high purity and is intended for research and radiochemistry applications where an amino handle is required for conjugation and labeling.
- High purity (99.89%) suitable for synthetic and radiochemistry use.
- Amino-functionalized derivative for conjugation and labeling.
- Trifluoroacetic acid salt form for improved handling and solubility.
- Intended for use as an intermediate in FAP-targeting radiotracer synthesis.
- Characterized by CAS number 2990021-73-1 and formula C23H24F5N5O5.
Medchemexpress LLC Ebiratide TFA | 99.0% | 996.23 | 5 MG
Ebiratide TFA (HOE-427) is an ACTH 4-9 derivative that acts directly on the central nervous system and shows memory-enhancing effects. It increases acetylcholine (ACh) metabolism in the rat brain. Ebiratide TFA has neuroprotective efficacy in mice models with electroconvulsive shock and Scopolamine-induced memory impairment, demonstrating anti-amnestic efficacy.
- ACTH 4-9 derivative.
- Acts directly on the central nervous system.
- Exhibits memory-enhancing efficacy.
- Enhances acetylcholine (ACh) metabolism in rat brain.
- Exhibits neuroprotective and anti-amnestic efficacy in animal models.
Medchemexpress LLC G-Pen-GRGDSPCA TFA | 111844-17-8 | 948.04 | 1 MG
G-Pen-GRGDSPCA TFA is a peptide identified by its CAS number 111844-17-8. It has a molecular weight of 948.04 and its molecular formula is C35H57N13O14S2. This compound is characterized by the IUPAC Condensed sequence H-Gly-Pen(1)-Gly-Arg-Gly-Asp-Ser-Pro-Cys(1)-Ala-OH.
- Peptide with the sequence GXGRGDSPCA
- Molecular formula C35H57N13O14S2
- Bicyclic heptapeptide structure with disulfide bonds
Medchemexpress LLC PF15 (TFA) | 99.7% | C46H50F3N13O8 | 25 MG
PF15 TFA is a PROTAC that connects ligands for FLT3 kinase and CRBN. It is a highly selective FLT3-ITD degrader with a DC50 of 76.7 nM. It significantly inhibits the proliferation of FLT3-ITD-positive cells and can down-regulate the phosphorylation of FLT3 and STAT5. It also inhibits tumor growth in mouse models and can be used in the study of leukemia.
- Connects ligands for FLT3 kinase and CRBN
- Highly selective FLT3-ITD degrader
- Has a DC50 of 76.7 nM
- Inhibits proliferation of FLT3-ITD-positive cells
- Down-regulates the phosphorylation of FLT3 and STAT5
- Inhibits tumor growth in mouse models
- Used in the study of leukemia
TARGETMOL CHEMICALS INC GSMTX4 TFA 1209500-46-8 5MG
Also available in 1 mg 2 mg 10 mg and bulk. Please contact Fisher for quotes. GsMTx4 TFA (1209500-46-8 free base) (GsMTx4 TFA) is a spider venom peptide that selectively inhibits cationic permeable mechanically-sensitive channels (MSCs) belonging to the Piezo and TRP channel families.
Medchemexpress LLC Abaloparatide TFA | 99.5% | 4074.61 | 25 MG
Abaloparatide TFA | 99.5% | 4074.61 | 25 MG
Medchemexpress LLC EZM0414 TFA | 2411759-92-5 | >97.2% | 514.51 | 1 ML
EZM0414 TFA, also known as SETD2-IN-1 TFA, is a potent, selective, and orally active inhibitor of SETD2 (IC50=18 nM in biochemical assay; IC50=34 nM in cellular assay). It is used for research into relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent, selective, and orally active SETD2 inhibitor.
- Inhibits proliferation of MM and DLBCL cell lines.
- Shows robust tumor growth regressions in xenograft models.
- Well-tolerated in animal studies.
- Exhibits high oral bioavailability in rats and mice.
- Soluble in DMSO and water for in vitro applications.
- Provides various in vivo solubility protocols for clear solutions.
Apexbio Technology LLC BIBP 3226 trifluoroacetate(Synonyms: BIBP3226 TFA, BIBP3226 trifluoroacetate salt, NPY Y1 receptor antagonist BIBP3226), 2mg, CAS: 1068148-47-9.
BIBP 3226 trifluoroacetate (CAS 1068148-47-9) is a non-peptide antagonist targeting neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptors showing binding affinity with Ki values of 1 1 nM (rNPY Y1) 79 nM (hNPFF2) and 108 nM (rNPFF) BIBP 3226 competes with NPFF prevents NPFF-induced inhibition of forskolin-stimulated cAMP production and blocks NPFF-dependent hypothermic and anti-opioid effects in rodent models This compound is employed experimentally to investigate NPY/NPFF system roles in anxiety analgesia and cardiovascular regulation
Medchemexpress LLC 6bK TFA | 1774353-12-6 | 99.7% | 871.94 | 25 MG
6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. It increases circulating insulin in high-fat-fed mice and enhances glucose tolerance to oral glucose, especially in high-fat-fed mice.
- Potent and selective insulin degrading enzyme (IDE) inhibitor
- IC50 value of 50 nM
- Increases circulating insulin in high-fat-fed mice
- Enhances glucose tolerance to oral glucose
- Suitable for type 2 diabetes research