Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Pgk13a TFA | 96.9% | 2004.73 (free base) | 5 MG
pGk13a TFA is an azide-containing amphiphilic membrane labeling probe. It enables high-resolution imaging of cell membranes in the ultrastructural membrane expansion microscopy (umExM) technique, facilitating the observation of membrane-associated structures and proteins. It can be used for neuronal structural studies.
- Azide-containing amphiphilic membrane labeling probe
- Enables high-resolution imaging of cell membranes
- Used in ultrastructural membrane expansion microscopy (umExM)
- Facilitates observation of membrane-associated structures and proteins
- Applicable for neuronal structural studies
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 4 x 2 mL
Trifluoroacetic acid | Purity: 99% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 4 x 2 mL
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 1KG
Trifluoroacetic acid, 76-05-1, MFCD00004169, 1KG
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 250G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 250G
Medchemexpress LLC Retatrutide TFA 10mg
Retatrutide, (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity. 10mg
Medchemexpress LLC GsMTx4 | 1209500-46-8 | 99.9% | 4095.84 | 500 UG
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. It also blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 serves as a pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
- Selectively inhibits cationic-permeable mechanosensitive channels
- Blocks cation-selective stretch-activated channels
- Attenuates lysophosphatidylcholine-induced astrocyte toxicity and microglial reactivity
- Neuroprotective and inhibits demyelination
- Reduces mechanical allodynia induced by inflammation and sciatic nerve injury
Medchemexpress LLC Cys-TAT(47-57) TFA | 98.1% | 1661.99 | 10 MG
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein. This product is intended for research use only and is not sold to patients.
- Purity: 98.1%
- Molecular weight: 1661.99 (free base)
- Appearance: Solid
- Color: White to off-white
- Solubility in H2O: 100 mg/mL (ultrasonic needed)
- Solubility in DMSO: ≥ 100 mg/mL
Medchemexpress LLC ATX-II (TFA) | 99.65% | 4934.62 (free acid) | 100 UG
ATX-II TFA is a selective sodium channel modulator toxin that enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. This compound exhibits a pro-arrhythmic effect by slowing intrinsic heart rate, prolonging the QT interval and sinus node recovery time, and inducing sinus pauses and arrests. It is suitable for research related to atrial fibrillation, long QT syndrome, and long QT3 syndrome.
- Enhances tetrodotoxin sensitive resurgent and persistent sodium currents in large diameter mouse DRG neurons.
- Shifts the voltage dependence of activation and steady-state fast inactivation of TTXS sodium channels to more hyperpolarized potentials.
- Increases diastolic tension and arrhythmia score in isolated rat right atrial tissue.
- Significantly increases diastolic intracellular Ca2+ concentrations in isolated rat atrial myocytes.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid HPLC | 76-05-1 | MFCD00004169 |
Trifluoroacetic acid HPLC | Purity: >=99.9% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 |
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic Acid | CAS 76-05-1
Trifluoroacetic Acid | Purity: >=99.0% | M. W.: 114.02 | 76-05-1 | 200-929-3
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus, 99, 76-05-1, MFCD00004169
Trifluoroacetic acid ReagentPlus, 99
Covachem Trifluoroacetic Acid | 76-05-1 | MFCD00004169 | 10 x 1 mL
This item has a minimum order quantity of 2 per supplier requirements.
Trifluoroacetic Acid | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 10 x 1 mL
Apexbio Technology LLC 10 mM dNTP Mixture 5x1ml
10 mM dNTP (2 -deoxynucleoside 5 -triphosphate) Mixture is an equimolar premixed aqueous solution containing four nucleotides (dATP dCTP dGTP and dTTP) each at a concentration of 10 mM The product is prepared as an aqueous solution titrated with NaOH to a neutral pH of 7 0