Acyl bromides
Medchemexpress LLC Roslin 2 bromide | 29574-21-8 | 99.0% | C13H19BrN4 | 1 MG
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that exhibits anticancer effects. It functions by binding to FAK, thereby disrupting the interaction between FAK and p53.
- Decreases cancer cell viability and clonogenicity in a p53-dependent manner.
- Increases p53 transcriptional activity, which is inhibited by FAK, using p21, Mdm-2, and Bax-promoter targets.
- Leads to increased expression of p53 targets: p21, Mdm-2, and Bax proteins.
- Significantly reduces tumor growth, disrupts the FAK and p53 complex, and up-regulates p21 in HCT116 p53+/+ xenografts (not in HCT116 p53-/- xenografts).
Medchemexpress LLC Oleyl bromide | 6110-53-8 | 98.36% | 331.37 | 50 MG
Oleyl bromide ((Z)-1-Bromooctadec-9-ene) is a hydrophobic compound capable of undergoing a ring-opening reaction through a process known as "encapsulation." It can also serve as a starting material in the synthesis of oleylphosphonates.
- Hydrophobic compound.
- Can carry out ring-opening reactions via "encapsulation."
- Used as a starting material in the synthesis of oleylphosphonates.
- Ships at room temperature in continental US.
- Pure form storage: -20°C for 3 years, 4°C for 2 years.
- In solvent storage: -80°C for 6 months, -20°C for 1 month.
Apexbio Technology LLC Methylbenactyzine-Bromide
Methylbenactyzine Bromide (CAS No 3166-62-9) is a synthetic anticholinergic agent primarily used in neuromuscular research Originating from studies on muscarinic receptor antagonists this compound targets muscarinic acetylcholine receptors inhibiting neurotransmission in cholinergic pathways Its efficacy is noted within the nanomolar to low micromolar range in in vitro assays making it a valuable tool in pharmacological studies focused on modulating neuronal activity The compound is commonly applied in cell models to explore neurophysiological processes and in animal studies to assess its impact on muscle relaxation and potential therapeutic effects for conditions like muscle spasms Additionally it serves as a reference compound in drug screening programs aimed at identifying new anticholinergic agents Experimental concentrations typically depend on the specific research design allowing for tailored applications across varied experimental settings
Apexbio Technology LLC Methylbenactyzine-Bromide
Methylbenactyzine Bromide (CAS No 3166-62-9) is a synthetic anticholinergic agent primarily used in neuromuscular research Originating from studies on muscarinic receptor antagonists this compound targets muscarinic acetylcholine receptors inhibiting neurotransmission in cholinergic pathways Its efficacy is noted within the nanomolar to low micromolar range in in vitro assays making it a valuable tool in pharmacological studies focused on modulating neuronal activity The compound is commonly applied in cell models to explore neurophysiological processes and in animal studies to assess its impact on muscle relaxation and potential therapeutic effects for conditions like muscle spasms Additionally it serves as a reference compound in drug screening programs aimed at identifying new anticholinergic agents Experimental concentrations typically depend on the specific research design allowing for tailored applications across varied experimental settings
Aobchem (4-(2-Bromoacetyl)phenyl)boronic acid | 97% | CAS 481725-47-7 | C8H8BBrO3 | 500mg
(4-(2-Bromoacetyl)phenyl)boronic acid | 97% | CAS 481725-47-7 | C8H8BBrO3 | 500mg
Apexbio Technology LLC Aclidinium Bromide 320345-99-1 10mM (in 1mL DMSO)
Aclidinium Bromide (CAS 320345-99-1) is a long-acting muscarinic antagonist (LAMA) that selectively inhibits muscarinic acetylcholine receptors In binding assays it demonstrates high affinity for M1 M5 receptor subtypes with Ki values of 0 10 0 21 nM Functional studies reveal greater potency at endogenous M2 and M3 receptors with EC50 values of 17 4 nM and 5 3 nM respectively In vivo aclidinium bromide produces a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction (EC50 2 5 23 1 g/mL in anesthetized guinea pigs) and suppresses pilocarpine-induced salivation in rats (EC50 38 g/kg) This compound is widely utilized in respiratory research for evaluating airway smooth muscle modulation via muscarinic receptor antagonism